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5467-74-3 - 4-Bromobenzeneboronic acid, 97+% - 4-Bromophenylboronic acid - L01565 - Alfa Aesar

L01565 4-Bromobenzeneboronic acid, 97+%

Codice CAS
5467-74-3
Sinonimi
4-Bromophenylboronic acid

Dimensioni Prezzo ($) Quantità Disponibilità
1g 19,50
5g 72,70
25g 300,00
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4-Bromobenzeneboronic acid, 97+%

MDL
MFCD00002104
EINECS
226-779-9

Proprietà chimiche

Formula
C6H6BBrO2
Peso formula
200.83
Punto di fusione
282-286°
Solubilità
Soluble in methanol. Insoluble in water.

Applicazioni

4-Bromobenzeneboronic acid is a reagent used for Palladium catalyzed Suzuki-Miyaura cross-couplings, Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation sequence. It is also used in the preparation of Protein modulators and enzymatic and kinase inhibitors, Gallate-based obovatol analogs with potential anti-tumor activity. It is used as a reagent for Copper-mediated ligandless aerobic fluoroalkylation of arylboronic acids with fluoroalkyl iodides, Pd-catalyzed arylative cyclization of alkyne-tethered enals or enones via carbopalladation of alkynes, Copper-catalyzed cross-couplings.

Note

Store in a cool and dark place. Store away from incompatible materials such as oxidizing agents. Incompatible with Oxidizing agents, Acids, Bases, Alcohols

Letteratura

GC reagent for diols: J. Chromat., 158, 33 (1978); 186, 307 (1979).

Carbonylative cross-coupling with iodobenzenes and CO, catalyzed by trans-Dichlorobis(triphenyl­phosphine)­palladium(II)­, 10491, gives unsymmetrical diaryl ketones: Tetrahedron Lett., 34, 7595 (1993); J. Org. Chem., 63, 4726 (1998). For reactions of boronic acids, see Appendix 5.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
2936347
Codice tariffe armonizzato
2931.90
TSCA
No
RTECS
CY8650000

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