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18871-66-4 - N,N-Dimethylacetamide dimethyl acetal, tech. 90%, stab with 5-10% methanol - L01642 - Alfa Aesar

L01642 N,N-Dimethylacetamide dimethyl acetal, tech. 90%, stab with 5-10% methanol

Codice CAS
18871-66-4
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
5g 44,40
25g 124,00
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N,N-Dimethylacetamide dimethyl acetal, tech. 90%, stab with 5-10% methanol

MDL
MFCD00008476
EINECS
242-641-0

Proprietà chimiche

Formula
C6H15NO2
Peso formula
133.19
Punto di ebollizione
118-120°
Punto di infiammabilità
8°(46°F)
Densità
0.911
Indice di rifrazione
1.4120
Sensibilità
Moisture Sensitive
Solubilità
Hydrolyzes in water.

Applicazioni

N,N-Dimethylacetamide dimethyl acetal is used as a reagent for the synthesis of amides, diacylamines, and heterocycles, one carbon inserting synthon in preparation of pyrimido[1,2-a][1,3,5]triazin-6-ones. It is used as intermediate in building block.

Note

Moisture Sensitive. Store at 2 - 8°C. Incompatible with strong oxidizing agents, Acids.

Letteratura

Richard K. Hill; Raghovan. Soman; Seiji. Sawada. Asymmetric induction in the thermal reactions of allylic alcohols with N,N-dimethylacetamide dimethylacetal and triethyl orthoacetate.J. Org. Chem.1972, 37 (23), 3737-3740.

Robert G. Salomon, Swadesh R. Raychaudhuri. Convenient preparation of N,N-dimethylacetamide dimethyl acetal.J. Org. Chem.1984, 49 (19), 3659-3660.

Reacts with 1,2-diols, e.g. sugars, to form 1-(dimethylamino)ethylidene cyclic acetals which can be cleaved with aqueous AcOH, giving the monoacetate of the less hindered OH, thus providing a method for selective monoprotection of the diol: Can. J. Chem., 50, 233 (1972).

Reacts with active methylene compounds to give the (dimethylamino)ethylidene derivatives: Liebigs Ann. Chem., 641, 1 (1961), compare N,N-Dimethyl­formamide dimethyl­ acetal, A15350.

For use in the N-acetylation of amides to give diacylamines (imides) in high yield, see: Synthesis, 119 (1980).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H370-H335-H302-H312-H332-H315-H319

Highly flammable liquid and vapour. Causes damage to organs. May cause respiratory irritation. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation.

Dichiarazioni precauzionali: P210-P260-P261-P280-P303+P361+P353-P305+P351+P338-P304+P340-P307+P311-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF exposed: Call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1420865
Classe di rischio
3
Gruppo di imballaggio
II
Codice tariffe armonizzato
2922.50
TSCA
No

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