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N,N-Dimethylacetamide dimethyl acetal is used as a reagent for the synthesis of amides, diacylamines, and heterocycles, one carbon inserting synthon in preparation of pyrimido[1,2-a][1,3,5]triazin-6-ones. It is used as intermediate in building block.
Richard K. Hill; Raghovan. Soman; Seiji. Sawada. Asymmetric induction in the thermal reactions of allylic alcohols with N,N-dimethylacetamide dimethylacetal and triethyl orthoacetate.J. Org. Chem.1972, 37 (23), 3737-3740.
Robert G. Salomon, Swadesh R. Raychaudhuri. Convenient preparation of N,N-dimethylacetamide dimethyl acetal.J. Org. Chem.1984, 49 (19), 3659-3660.
Reacts with 1,2-diols, e.g. sugars, to form 1-(dimethylamino)ethylidene cyclic acetals which can be cleaved with aqueous AcOH, giving the monoacetate of the less hindered OH, thus providing a method for selective monoprotection of the diol: Can. J. Chem., 50, 233 (1972).
Reacts with active methylene compounds to give the (dimethylamino)ethylidene derivatives: Liebigs Ann. Chem., 641, 1 (1961), compare N,N-Dimethylformamide dimethyl acetal, A15350.
For use in the N-acetylation of amides to give diacylamines (imides) in high yield, see: Synthesis, 119 (1980).
Dichiarazioni di rischio (UE): H225-H302-H312-H332-H315-H319-H370-H335
Highly flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. Causes damage to organs. May cause respiratory irritation.
Dichiarazioni precauzionali: P210-P260-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.