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776-74-9 - Benzhydryl bromide, 90+% - Bromodiphenylmethane - Diphenylmethyl bromide - L02211 - Alfa Aesar

L02211 Benzhydryl bromide, 90+%

Codice CAS
776-74-9
Sinonimi
Bromodiphenylmethane
Diphenylmethyl bromide

Dimensioni Prezzo ($) Quantità Disponibilità
25g 21,00
100g 43,20
500g 159,00
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Benzhydryl bromide, 90+%

MDL
MFCD00000134
EINECS
212-279-8

Proprietà chimiche

Formula
C13H11Br
Peso formula
247.14
Punto di fusione
36-41°
Punto di ebollizione
183-185°/20mm
Punto di infiammabilità
>110°(230°F)
Sensibilità
Moisture Sensitive
Solubilità
Insoluble in water.

Applicazioni

Benzhydryl bromide is a halogenated building block. Benzhydryl group was preferred to the commoner benzyl to protect 2-nitrophenol in the Bartoli (vinyl Grignard) synthesis of 7-hydroxyindole. Protection was by reaction with the phenol in the presence of potassium carbonate in acetone; deprotection of the indole was by hydrogenolysis.

Note

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents and bases. It is sensitive to moisture. Protect from humidity and water. Store under dry inert gas.

Letteratura

S. Winstein.; Arnold H. Fainberg.; E. Grunwald. Correlation of Solvolysis Rates. VIII. Benzhydryl Chloride and Bromide. Comparison of mY and Swain's Correlations. J. Am. Chem. Soc. 1957, 79 (15), 4146-4155.

Anu Mahadevan.; Howard Sard.; Mario Gonzalez.; John C. McKew. A general method for C3 reductive alkylation of indoles. Tetrahedron Letters. 2003, 44(24), 4589-4591.

The benzhydryl group was preferred to the commoner benzyl to protect 2-nitrophenol in the Bartoli (vinyl Grignard) synthesis of 7-hydroxyindole. Protection was by reaction with the phenol in the presence of potassium carbonate in acetone; deprotection of the indole was by hydrogenolysis: Synth. Commun., 21, 611 (1991).

Compare also Benzhydrol, A12884.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P280-P305+P351+P338-P309-P310a

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell:

Altri riferimenti

Beilstein
638544
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2903.99
TSCA
Yes
RTECS
PA5350000

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