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19012-03-4 - 1-Methylindole-3-carboxaldehyde, 98+% - 3-Formyl-1-methylindole - L02212 - Alfa Aesar

L02212 1-Methylindole-3-carboxaldehyde, 98+%

Codice CAS
19012-03-4
Sinonimi
3-Formyl-1-methylindole

Dimensioni Prezzo ($) Quantità Disponibilità
1g 28,30
5g 80,60
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1-Methylindole-3-carboxaldehyde, 98+%

MDL
MFCD00014570
EINECS
242-750-3

Proprietà chimiche

Formula
C10H9NO
Peso formula
159.19
Punto di fusione
67-71°
Sensibilità
Air Sensitive
Solubilità
Insoluble in water.

Applicazioni

1-Methylindole-3-carboxaldehyde is used as a reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions, reactant for synthesis of quinolinones via three-component Ugi reaction, reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture, reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins, reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent, reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents 1-Methylindole-3-carboxaldehyde may be used in the synthesis of (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile, via base-catalyzed condensation with thiophene-3-acetonitrile. It was also used in the preparation of monomer, required for the synthesis of poly(3-vinyl-1-methylindole).

Note

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. Store under dry inert gas. It is sensitive to air.

Letteratura

Ahmed Abouabdellah.; Robert H. Dodd. A new approach to the synthesis of functionalized pyrido[2,3-b]indoles by way of a palladium-catalyzed ring closing reaction between the N-1 and C-9a positionsn. Tetrahedron Letters. 1998, 31 (15), 2119-2122.

Haiming Zhang.; Richard C Larock. Synthesis of β- and γ-carbolines by the palladium/copper-catalyzed coupling and copper-catalyzed or thermal cyclization of terminal acetylenes. Tetrahedron Letters. 2002, 43(8), 1359-1362.

Altri riferimenti

Beilstein
121302
Codice tariffe armonizzato
2933.99
TSCA
No

Raccomandato

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    Tetrakis(triphenylphosphine)palladium(0), 99.8% (metals basis), Pd 9% min

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