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2049-80-1 - Diethyl allylmalonate, 96% - Allylmalonic acid diethyl ester - L02286 - Alfa Aesar

L02286 Diethyl allylmalonate, 96%

Codice CAS
2049-80-1
Sinonimi
Allylmalonic acid diethyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
25g 29,30
100g 76,10
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Diethyl allylmalonate, 96%

MDL
MFCD00009155
EINECS
218-072-9

Proprietà chimiche

Formula
C10H16O4
Peso formula
200.23
Punto di ebollizione
222-223°
Punto di infiammabilità
92°(197°F)
Densità
1.016
Indice di rifrazione
1.4310
Solubilità
Not miscible or difficult to mix with water.

Applicazioni

Diethyl allylmalonate is an important intermediates in syntheses of vitamins B1 and B6, barbiturates, non-steroidal anti-inflammatory agents, other numerous pharmaceuticals, agrochemicals and flavors and fragrances compounds.

Note

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Letteratura

Barry M. Trost.; Andrew H. Weiss.; Axel Jacobi von Wangelin. Dinuclear Zn-Catalyzed Asymmetric Alkynylation of Unsaturated Aldehydes. J. Am. Chem. Soc. 2006, 128 (1), 8-9.

Miwako Mori. Synthesis of Natural Products and Related Compounds using Enyne Metathesis. Advanced Synthesis & Catalysis. 2007, 349(1-2), 121-135.

Alkylation at the one available acidic hydrogen, followed by removal of the allyl group with the reagent (2-propene)Ti(O-i-Pr)2, readily prepared from Ti(O-i-Pr)4 and i-PrMgCl, gives the mono-alkyl malonate. Diethyl allylmalonate can thus be regarded as a mono-protected form of diethyl malonate: J. Org. Chem., 61, 2266 (1996):

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Dichiarazioni precauzionali: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1709466
Codice tariffe armonizzato
2917.19
TSCA
Yes

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