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2-Propanesulfonyl chloride is used as a pharmaceutical intermediate. Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride.
James F. King.; Joe Y. L. Lam.; Vinod Dave. tert-Butyl Cation Formation in the Hydrolysis of 2-Methyl-2-propanesulfonyl Chloride, the Simplest Tertiary Alkanesulfonyl Chloride. J. Org. Chem. 1995, 60 (9), 2831-2834.
Dennis N. Kevill.; Byoung-Chun Park.; Kyoung-Ho Park.; Malcolm J. D'Souza.; Lamia Yaakoubd.; Stacey L. Mlynarski.; Jin Burm Kyong. Rate and product studies in the solvolyses of N,N-dimethylsulfamoyl and 2-propanesulfonyl chlorides. Org. Biomol. Chem. 2006, 4(8), 1580-1586.
Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride. Reduction of the mesylate and tosylate yielded only the starting alcohol: J. Am. Chem. Soc., 107, 4088 (1985).
Dichiarazioni di rischio (UE): H227-H314-H318
Combustible liquid. Causes severe skin burns and eye damage. Causes serious eye damage.
Dichiarazioni precauzionali: P210u-P260u-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.