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38870-89-2 - Methoxyacetyl chloride, 97%, stab. with ca 0.3% magnesium oxide - L03210 - Alfa Aesar

L03210 Methoxyacetyl chloride, 97%, stab. with ca 0.3% magnesium oxide

Codice CAS
38870-89-2
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
5g 38,40
25g 116,00
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Methoxyacetyl chloride, 97%, stab. with ca 0.3% magnesium oxide

MDL
MFCD00000728
EINECS
254-169-2

Proprietà chimiche

Formula
CH3OCH2COCl
Peso formula
108.52
Punto di fusione
<-40°
Punto di ebollizione
112-113°
Punto di infiammabilità
28°(82°F)
Densità
1.185
Indice di rifrazione
1.4240
Sensibilità
Moisture Sensitive
Solubilità
Miscible with acetone, ether, carbon tetrachloride and chloroform.

Applicazioni

Methoxyacetyl chloride is used as an intermediate for active pharmaceutical ingredients and dyes. Further, it acts as a precursor for the synthesis of agrochemicals.

Note

Moisture sensitive. Store in a cool place. Incompatible with water, alcohols, oxidizing agents and strong bases.

Letteratura

Reagent for the chloromethylation of aromatics under Friedel-Crafts conditions, avoiding the use of chloromethyl methyl ether: Tetrahedron Lett., 24, 1933 (1983). For a study of the kinetics of chloromethylation of benzene and toluene in the presence of SnCl4, see: J. Org. Chem., 62, 2694 (1997). Compare Methoxyacetic acid, B22917.

Has also been used for the protection of alcohols as methoxyacetate esters, formed in the presence of pyridine, and cleaved using methanolic or aqueous ammonia ca. 20x faster than acetate: Tetrahedron Lett., 4273 (1968). Selective cleavage with Yb(OTf)3: J. Org. Chem., 61, 4491 (1996), or ethanolamine in IPA: J. Org. Chem., 60, 331 (1995), have also been reported.

Tiwari, D. K.; Pogula, J.; Tiwari, D. K. A general and practical route to 4,5-disubstituted oxazoles using acid chlorides and isocyanides. RSC Adv. 2015, 5 (65), 53111-53116.

Zadehahmadi, F.; Ahmadi, F.; Tangestaninejad, S.; Moghadam, M.; Mirkhani, V.; Mohammadpoor-Baltork, I.; Kardanpour, R. Catalytic CO2 fixation using tin porphyrin supported on organic and inorganic materials under mild conditions. J. Mol. Catal. A: Chem. 2015, 398, 1-10.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H226-H331-H314-H318

Flammable liquid and vapour. Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P280-P305+P351+P338-P309-P310a

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell:

Altri riferimenti

Beilstein
1740244
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2918.99
TSCA
No

Raccomandato

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    Sulfur trioxide-pyridine complex, 98%, active SO3 ca 48-50%
  • A12511

    Glycolic acid, 98%
  • H34443

    2-Ethoxyacetyl chloride, 97%, stab. with 0.3% Magnesium oxide

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