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34097-60-4 - Methyl phenylsulfonylacetate, 98% - Phenylsulfonylacetic acid methyl ester - L03748 - Alfa Aesar

L03748 Methyl phenylsulfonylacetate, 98%

Codice CAS
34097-60-4
Sinonimi
Phenylsulfonylacetic acid methyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
5g 22,00
25g 65,90
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Methyl phenylsulfonylacetate, 98%

MDL
MFCD00007555

Proprietà chimiche

Formula
C9H10O4S
Peso formula
214.24
Punto di fusione
ca 30°
Punto di ebollizione
165°/0.05mm
Punto di infiammabilità
>110°(230°F)
Densità
1.240
Indice di rifrazione
1.5350
Solubilità
Insoluble in water.

Applicazioni

Methyl phenylsulfonylacetate has been used in a key step during the synthesis of (-)-hybridalactone, marine eicosanoid isolated from the red alga Laurencia hybrida, in dehydrative alkylation of alcohols under modified Mitsunobu conditions followed by desulfonylation using magnesium, in three step synthesis of 2-(hydroxymethyl)indene.

Note

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Letteratura

Koichiro Ota; Naoto Sugata; Yoshihiko Ohshiro; Etsuko Kawashima; Hiroaki Miyaoka. Total synthesis of marine eicosanoid (-)-hybridalactone. Chemistry: A European Journal. 2012, 18, (42), 13531-13537.

Yu J.; Lai J.-Y.; Falck J. R. Methyl Carboxymethylenation of Alcohols via Dehydrative Alkylation. Journal of Allergy and Clinical Immunology. 1995, (11), 1127-1128.

Active methylene compound used by Trost in Pd-catalyzed additions to allylic systems, providing, after desulfonation, methoxycarbonylmethyl derivatives under neutral conditions; see, e.g.: J. Am. Chem. Soc., 100, 3435 (1978); 103, 5969 (1981):

See also: Tetrahedron Lett., 33, 1831 (1992). Desulfonation has been effected with Na amalgam: Tetrahedron Lett., 3477 (1976), Ca in liquid ammonia: J. Am. Chem. Soc., 100, 3435 (1978); or Mg in methanol: J. Org. Chem., 50, 1749 (1985).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni precauzionali: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
2051463
Codice tariffe armonizzato
2930.90
TSCA
No

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