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50-28-2 - beta-Estradiol, 99% (dry wt.), ca 3% water - (8R,9S,13S,14S,17S)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol - L03801 - Alfa Aesar

L03801 beta-Estradiol, 99% (dry wt.), ca 3% water

Codice CAS
50-28-2
Sinonimi
(8R,9S,13S,14S,17S)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

Dimensioni Prezzo ($) Quantità Disponibilità
1g 32,04
5g 111,60
25g 388,80
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beta-Estradiol, 99% (dry wt.), ca 3% water

MDL
MFCD00003693
EINECS
200-023-8

Proprietà chimiche

Formula
C18H24O2
Peso formula
272.39
Punto di fusione
175-178°
Solubilità
Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.

Applicazioni

β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner's syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.

Note

Incompatible with strong oxidizing agents.

Letteratura

Liu, X.; Liu, Y.; Cheng, M.; Zhang, X.; Xiao, H. A metabolomics study of the inhibitory effect of 17-beta-estradiol on osteoclast proliferation and differentiation. Mol. Biosyst. 2015, 11 (2), 635-646.

Pooley, A. E.; Luong, M.; Hussain, A.; Nathan, B. P. Neurite outgrowth promoting effect of 17-beta estradiol is mediated through estrogen receptor alpha in an olfactory epithelium culture. Brain Res. 2015, 1624, 19-27.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H350-H360

May cause cancer. May damage fertility or the unborn child.

Dichiarazioni precauzionali: P201-P281-P202-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,3703
Beilstein
1914275
Codice tariffe armonizzato
2906.19
TSCA
No
RTECS
KG2975000

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