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British Anti-Lewisite. A chelator that inhibits sugar nucleotide degradation.2,3-Dimercaptopropanol is used as a chelating agent involved in the treatment of arsenic, antimony, lead, gold and mercury poisoning. It is also used as an antidote to the warfare agent Lewisite. Further, it is used for the treatment of Wilson's disease. In addition to this, it is used as an adjunct in the treatment of the acute encephalopathy of lead toxicity.
Chio, C. M.; Cheng, K. W.; Bishop, A. C. Direct Chemical Activation of a Rationally Engineered Signaling Enzyme. ChemBioChem 2015, 16 (12), 1735-1739.
Andries, C.; Manea, M.; Drochioiu, G.; Gradinaru, R. New insights into coenzyme A interaction with mercury ions provided by mass spectrometric and circular dichroism spectroscopic approaches. Eur. J. Mass Spectrom. 2015, 21 (2), 97-102.
Dichiarazioni di rischio (UE): H301-H315-H319-H317
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction.
Dichiarazioni precauzionali: P261-P280a-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.