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Chloro(methyl)diphenylsilane is used in agrochemical, pharmaceutical and dyestuff field .
Filippo Marchioni; Kurt Star; Erik Menke; Thierry Buffeteau; Laurent Servant; Bruce Dunn and Fred Wud. Protection of Lithium Metal Surfaces Using Chlorosilanes.Anal. Chem.2007, 23 (23), 11597-11602.
Silylating agent (see Appendix 4) for formation, in the presence of a base such as imidazole in DMF, of DPMS ethers, intermediate in hydrolytic stabilty between TMS and TBDMS. DPMS ethers are incompatible with acid, base, BuLi, Cr(VI) oxidants and LIAlH4, but stable to silica chromatography: J. Org. Chem., 52, 165 (1987). They can be cleaved with mild acid or base, or F-. Selective cleavage in high yield in the presence of TBDMS or TBDPS ethers with NaN3 in DMF was reported: J. Chem. Soc., Chem. Commun., 381 (1989).
In reactions with lithiated esters and lactones C-silylation predominates. The resulting ɑ-DPMS esters behave as vinyl dication equivalents: J. Am. Chem. Soc., 103, 2418 (1981); Pure Appl. Chem., 62, 2021 (1990), useful precursors of, e.g.: terminal alkenes: Synth. Commun., 13, 1163 (1983); 1,1-disubstituted alkenes: Tetrahedron Lett., 23, 271 (1982); Org. Synth. Coll., 8, 474 (1993); ß-keto silanes and ketones: J. Org. Chem., 50, 5260 (1985); 58, 2718 (1993):
TBDMS esters react with aldehydes and ketones to give ß-hydroxy silanes, which undergo Peterson elimination to ɑ-substituted ɑß-unsaturated esters: J. Org. Chem., 49, 3385 (1984).
Dichiarazioni di rischio (UE): H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.