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96-53-7 - 2-Mercaptothiazoline, 98+% - 2-Thiazolinethiol - L04924 - Alfa Aesar

L04924 2-Mercaptothiazoline, 98+%

Codice CAS
96-53-7
Sinonimi
2-Thiazolinethiol

Dimensioni Prezzo ($) Quantità Disponibilità
100g 30,10
500g 114,00
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2-Mercaptothiazoline, 98+%

MDL
MFCD00126013
EINECS
202-512-1

Proprietà chimiche

Formula
C3H5NS2
Peso formula
119.21
Punto di fusione
103-107°
Solubilità
Soluble in chloroform, methanol. Slightly soluble in water.

Applicazioni

2-Mercaptothiazoline, is used in the chain-lengthening of alkyl halides by trans-iodopropenylenation. 2-Mercaptothiazoline is an antithyroid agent that strongly reduces thyroid hormone levels. 2-Mercaptothiazoline is also used as an intermediate in the preparation of biologically active compounds. It is also used as a tool for highly selective chiral synthesis of penam- and carbapenam-type β-lactam antibiotics.

Note

Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.

Letteratura

Lei Tao et. al. Synthesis and bioactivity of poly(HPMA)-lysozyme conjugates: the use of novel thiazolidine-2-thione coupling chemistry. Organic & Biomolecular Chemistry. span>2009, 7,(17), 3481-3485 .

Newton L Dias Filho et. al. Preparation of a clay-modified carbon paste electrode based on 2-thiazoline-2-thiol-hexadecylammonium sorption for the sensitive determination of mercury. Analytical Sciences. span>2005, 21,(11), 1309-1316 .

Used in the chain-lengthening of alkyl halides by trans-iodopropenylenation: Org. Synth. Coll., 6, 704 (1988):

Reaction with ɑ-bromo esters gives the S-alkoxycarbonylmethyl derivatives, which can be C-alkylated by alkyl halides, using NaH as base. Sulfur-free products can be obtained by reduction (Zn/AcOH) to give the substituted acetic acid, or by reaction with iodidomethane to give the corresponding ɑ-iodo ester: Tetrahedron Lett., 2677 (1977).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H301

Toxic if swallowed.

Dichiarazioni precauzionali: P260u-P201-P280h-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/clothing. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
106332
Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2934.10
TSCA
Yes
RTECS
XJ6122000

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