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677-43-0 - N,N-Dimethylphosphoramidodichloridate, 97% - Dimethylaminophosphoryl dichloride - N,N-Dimethylphosphoramic dichloride - L07231 - Alfa Aesar

L07231 N,N-Dimethylphosphoramidodichloridate, 97%

Codice CAS
677-43-0
Sinonimi
Dimethylaminophosphoryl dichloride
N,N-Dimethylphosphoramic dichloride

Dimensioni Prezzo ($) Quantità Disponibilità
5g 45,63
25g 144,20
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N,N-Dimethylphosphoramidodichloridate, 97%

MDL
MFCD00013896
EINECS
211-641-2

Proprietà chimiche

Formula
C2H6Cl2NOP
Peso formula
161.96
Punto di ebollizione
89-90°/20mm
Punto di infiammabilità
>110°(230°F)
Densità
1.360
Indice di rifrazione
1.4630
Sensibilità
Moisture Sensitive
Solubilità
Miscible with dimethoxyethane.

Applicazioni

N,N-Dimethylphosphoramidodichloridate is used in the synthesis of phosphoramidates as well as (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA) which is used as a chemical weapon. It forms active intermediates, which react with alcohols in situ to give esters. It is also used to convert primary alcohols to alkyl chlorides. Furthe, it serves as an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. In addition to this, it reacts with 1,2 diols to prepare cyclic phosphoric amides followed by alkenes after reduction.

Note

Moisture and air sensitive. Hygroscopic. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Letteratura

With 1,2-diols forms cyclic phosphoric amides which can be reduced to alkenes, e.g. with Na in xylene: Synth. Commun., 5, 293 (1975).

In the presence of pyridine, carboxylic acids form active intermediates which react with alcohols in situ to give esters: Tetrahedron Lett., 4461 (1978). Has also been used to convert primary alcohols to alkyl chlorides: Chem. Lett., 923 (1978).

Wils, E. R. Mass spectral data of precursors of chemical warfare agents. Fresenius J. Anal. Chem. 1990, 338 (1), 22-27.

Santilli, A. A.; Morris, R. L.; Scotese, A. C.; Strike, D. P. A convenient synthesis of N-[2-[[[5-[(dimethlamino methyl]-2-furanylmethyl]thio]ethyl]thieno-[3, 4-d]isothiazol-3-amine-1,1-dioxide hydrochloride,a potent gastric acid antisecretory agent. Org. Prep. Proced. Int. 1990, 22 (1), 71-76.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
969956
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2931.90
TSCA
No
RTECS
TB4025000

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