Informativa e consenso per l'uso dei cookie

Accetto Il nostro sito salva piccoli pezzi di informazioni (cookie) sul dispositivo, al fine di fornire contenuti migliori e per scopi statistici. È possibile disattivare l'utilizzo di cookies modificando le impostazioni del tuo browser. Continuando la navigazione si acconsente all'utilizzo dei cookie.

3222-47-7 - 6-Methylnicotinic acid, 99% - 6-Methylpyridine-3-carboxylic acid - L08877 - Alfa Aesar

L08877 6-Methylnicotinic acid, 99%

Codice CAS
3222-47-7
Sinonimi
6-Methylpyridine-3-carboxylic acid

Dimensioni Prezzo ($) Quantità Disponibilità
1g 34,10
5g 101,00
25g 402,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

6-Methylnicotinic acid, 99%

MDL
MFCD00006341
EINECS
000-000-0

Proprietà chimiche

Formula
C7H7NO2
Peso formula
137.14
Punto di fusione
210-215°
Solubilità
Sparingly soluble in water.

Applicazioni

6-Methylnicotinic acid is an intermediate of the drug etoricoxib (a non- steroidal anti-inflammatory drug for the treatment of arthritis and osteoarthritis). It is also used as organic intermediates.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents. Store away from oxidizing agents.

Letteratura

Andreas Tinschert; Andreas Kiener; Klaus Heinzmann; A. Tschech. Isolation of new 6-methylnicotinic-acid-degrading bacteria, one of which catalyses the regioselective hydroxylation of nicotinic acid at position C2.Archives of Microbiology.1997, 168 355-361.

B.-M. Kukovec; Z. Popovic and G. Pavlovic. A new coordination mode of 6-methyl­nicotinic acid in trans-tetra­aquabis­(6-methyl­pyridine-3-carboxyl­ato-[kappa]O)cobalt(II) tetra­hydrate.Acta Cryst.2007, C63 m615-m617.

Dilithiation can be effected with LDA, allowing substitution at the 6-methyl group, as, for example carboxylation in the synthesis of methotrexate analogues: J. Med. Chem., 40, 370 (1997).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
112049
Codice tariffe armonizzato
2933.39
TSCA
No

Raccomandato

  • A11223

    6-Aminonicotinic acid, 98%
  • A12683

    Nicotinic acid, 99%
  • B22873

    Cystamine dihydrochloride, 97+%
  • L19845

    2-Aminopyridine-4-carboxylic acid, 96%
  • H33003

    2-Methyl-6-(trifluoromethyl)nicotinic acid, 97%

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio