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990-91-0 - Tetrabenzyl pyrophosphate, 98% - Pyrophosphoric acid tetrabenzyl ester - L09083 - Alfa Aesar

L09083 Tetrabenzyl pyrophosphate, 98%

Codice CAS
990-91-0
Sinonimi
Pyrophosphoric acid tetrabenzyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 57,40
1g 160,00
5g 618,00
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Tetrabenzyl pyrophosphate, 98%

MDL
MFCD00051941

Proprietà chimiche

Formula
C28H28O7P2
Peso formula
538.48
Punto di fusione
58-64°
Sensibilità
Moisture Sensitive
Solubilità
Slightly soluble in water.

Applicazioni

Tetrabenzyl pyrophosphate is used in the preparation of phosphoryl derivatives of shikimic acid in the presence of LDA. It is used in the preparation of dibenzyl phosphoro fluoridate in the presence of cesium fluoride as a catalyst. It is also used as a precursor in pharmaceuticals and involved in the phosphorylation of inositol derivatives.

Note

Moisture sensitive. Incompatible with strong oxidizing agents, strong acid and bases and reducing agents.

Letteratura

Useful reagent for O-phosphorylation. Used in preparation of phosphoryl derivatives of shikimic acid, by reaction in the presence of LDA; subsequent debenzylation was accomplished with TMS bromide: J. Org. Chem, 51, 75 (1986). Used to phosphorylate inositol derivatives in the presence of KH or NaH in THF: J. Am. Chem. Soc., 109, 3478 (1987); J. Chem. Soc., Chem. Commun., 298 (1991); the required debenzylated products were obtained by catalytic hydrogenolysis.

Forget, S. M.; Jee, A.; Smithen, D. A.; Jagdhane, R.; Anjum, S.; Beaton, S. A.; Palmer, D. R. J.; Syvitski, R. T.; Jakeman, D. L. Kinetic evaluation of glucose 1-phosphate analogues with a thymidylyltransferase using a continuous coupled enzyme assay. Org. Biomol. Chem. 2015, 13 (3), 866-875.

Ghaedi, M.; Jaberi, S. Y. S.; Hajati, S.; Montazerozohori, M; Asfaram, A.; Zareh, M. Modified Carbon Paste Electrode for Pb2+ Ion Determination: Response Surface Methodology. IEEE Sensors J. 2015, 15 (5), 2974 - 2983.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
2068292
Classe di rischio
8
Gruppo di imballaggio
III
Codice tariffe armonizzato
2919.90
TSCA
No

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