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4-Pentynoic acid is widely utilized as a building block for the synthesis of eight sequence-defined model oligomers. Due to its triple bond at terminal carbon, it is employed as an intermediate to produce biologically active compounds. It is used as a hypoglycemic agent, which increases liver tyrosine aminotransferase and plasma corticosterone while decreasing blood sugar in rats.
Belger, K.; Krause, N. Smaller, faster, better: modular synthesis of unsymmetrical ammonium salt-tagged NHC-gold(I) complexes and their application as recyclable catalysts in water. Org. Biomol. Chem. 2015, 13 (31), 8556-8560.
Sahariah, P.; Sørensen, K. K.; Hjálmarsdóttir, M. A.; Sigurjónsson, O. E.; Jensen, K. J.; Másson, M.; Thygesen, M. B. Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers. Chem. Commun. 2015, 51 (58), 11611-11614.
Hamano, H.; Nagata, K.; Fukada, N.; Shimotahira, H.; Ju, X.; Ozoe, Y. 5-[4-(3,3-Dimethylbutoxycarbonyl)phenyl]-4-pentynoic acid and its derivatives inhibit ionotropic γ-aminobutyric acid receptors by binding to the 4'-ethynyl-4-n-propylbicycloorthobenzoate site. Bioorg. Med. Chem. 2000, 8 (3), 665-674.
Dichiarazioni di rischio (UE): H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Dichiarazioni precauzionali: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.