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6089-09-4 - 4-Pentynoic acid, 95% - Propargylacetic acid - L09282 - Alfa Aesar

L09282 4-Pentynoic acid, 95%

Codice CAS
6089-09-4
Sinonimi
Propargylacetic acid

Dimensioni Prezzo ($) Quantità Disponibilità
1g 47,50
5g 168,00
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4-Pentynoic acid, 95%

MDL
MFCD00004407
EINECS
228-028-0

Proprietà chimiche

Formula
C5H6O2
Peso formula
98.10
Punto di fusione
51-58°
Punto di ebollizione
109-110°/30mm
Punto di infiammabilità
75°(167°F)
Sensibilità
Light & Air Sensitive & Hygroscopic
Solubilità
Soluble in low polarity organic solvents. Soluble in water.

Applicazioni

4-Pentynoic acid is widely utilized as a building block for the synthesis of eight sequence-defined model oligomers. Due to its triple bond at terminal carbon, it is employed as an intermediate to produce biologically active compounds. It is used as a hypoglycemic agent, which increases liver tyrosine aminotransferase and plasma corticosterone while decreasing blood sugar in rats.

Note

Keep the container tightly closed in a dry and well-ventilated place. Incompatible with bases, oxidizing agents and reducing agents.

Letteratura

Belger, K.; Krause, N. Smaller, faster, better: modular synthesis of unsymmetrical ammonium salt-tagged NHC-gold(I) complexes and their application as recyclable catalysts in water. Org. Biomol. Chem. 2015, 13 (31), 8556-8560.

Sahariah, P.; Sørensen, K. K.; Hjálmarsdóttir, M. A.; Sigurjónsson, O. E.; Jensen, K. J.; Másson, M.; Thygesen, M. B. Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers. Chem. Commun. 2015, 51 (58), 11611-11614.

Hamano, H.; Nagata, K.; Fukada, N.; Shimotahira, H.; Ju, X.; Ozoe, Y. 5-[4-(3,3-Dimethylbutoxycarbonyl)phenyl]-4-pentynoic acid and its derivatives inhibit ionotropic γ-aminobutyric acid receptors by binding to the 4'-ethynyl-4-n-propylbicycloorthobenzoate site. Bioorg. Med. Chem. 2000, 8 (3), 665-674.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1742047
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2916.19
TSCA
No
RTECS
SC4751000

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