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17145-91-4 - Triethyl 2-phosphonobutyrate, 97% - Diethyl 1-(ethoxycarbonyl)propanephosphonate - 2-Phosphonobutyric acid triethyl ester - L09329 - Alfa Aesar

L09329 Triethyl 2-phosphonobutyrate, 97%

Codice CAS
17145-91-4
Sinonimi
Diethyl 1-(ethoxycarbonyl)propanephosphonate
2-Phosphonobutyric acid triethyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
5g 34,40
25g 126,00
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Triethyl 2-phosphonobutyrate, 97%

MDL
MFCD00041347

Proprietà chimiche

Formula
C10H21O5P
Peso formula
252.25
Punto di ebollizione
105-106°/2mm
Punto di infiammabilità
>110°(230°F)
Densità
1.064
Indice di rifrazione
1.4330
Solubilità
Not miscible or difficult to mix with water.

Applicazioni

Reactant used for preparation of furospinosulin-1 and analogs as hypoxia-selective antitumor agents, Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer?s drugs, phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents, PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists, notch-sparing γ-secretase inhibitors derived from PPAR agonist library and plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis.

Note

Store in cool. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Letteratura

Yuan Cheng et. al. From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).. Journal of medicinal and pharmaceutical chemistry,2011, 54 (16), 5836-5857.

Shintaro Ban et. al. Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists. Bioorganic & Medicinal Chemistry,2011, 19(10), 3183-3191.

Intermediate for Wadsworth-Emmons formation of ɑ-ethylacrylic esters. See Appendix 1.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Dichiarazioni precauzionali: P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313

Wear protective gloves and eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists:

Altri riferimenti

Beilstein
1789280
Codice tariffe armonizzato
2931.39
TSCA
No

Raccomandato

  • A13200

    2,4-Hexadienal, predominantly trans,trans, 95%
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    Isobutyltriphenylphosphonium bromide, 98+%
  • 11475

    Molybdenum rod, 5mm (0.2in) dia, Puratronic®, 99.97% (metals basis)
  • H53439

    3-Methyl-1-butyne, 96%

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