Informativa e consenso per l'uso dei cookie

Accetto Il nostro sito salva piccoli pezzi di informazioni (cookie) sul dispositivo, al fine di fornire contenuti migliori e per scopi statistici. È possibile disattivare l'utilizzo di cookies modificando le impostazioni del tuo browser. Continuando la navigazione si acconsente all'utilizzo dei cookie.

17145-91-4 - Triethyl 2-phosphonobutyrate, 97% - Diethyl 1-(ethoxycarbonyl)propanephosphonate - 2-Phosphonobutyric acid triethyl ester - L09329 - Alfa Aesar

L09329 Triethyl 2-phosphonobutyrate, 97%

Codice CAS
17145-91-4
Sinonimi
Diethyl 1-(ethoxycarbonyl)propanephosphonate
2-Phosphonobutyric acid triethyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
5g 34,40
25g 126,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

Triethyl 2-phosphonobutyrate, 97%

MDL
MFCD00041347

Proprietà chimiche

Formula
C10H21O5P
Peso formula
252.25
Punto di ebollizione
105-106°/2mm
Punto di infiammabilità
>110°(230°F)
Densità
1.064
Indice di rifrazione
1.4330
Solubilità
Not miscible or difficult to mix with water.

Applicazioni

Reactant used for preparation of furospinosulin-1 and analogs as hypoxia-selective antitumor agents, Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer?s drugs, phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents, PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists, notch-sparing γ-secretase inhibitors derived from PPAR agonist library and plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis.

Note

Store in cool. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Letteratura

Yuan Cheng et. al. From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).. Journal of medicinal and pharmaceutical chemistry,2011, 54 (16), 5836-5857.

Shintaro Ban et. al. Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists. Bioorganic & Medicinal Chemistry,2011, 19(10), 3183-3191.

Intermediate for Wadsworth-Emmons formation of ɑ-ethylacrylic esters. See Appendix 1.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Dichiarazioni precauzionali: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Altri riferimenti

Beilstein
1789280
Codice tariffe armonizzato
2931.90
TSCA
No

Raccomandato

  • A13200

    2,4-Hexadienal, predominantly trans,trans, 95%
  • A17881

    Isobutyltriphenylphosphonium bromide, 98+%
  • 11475

    Molybdenum rod, 5mm (0.2in) dia, Puratronic®, 99.97% (metals basis)
  • H53439

    3-Methyl-1-butyne, 96%

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio