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17176-77-1 - Dibenzyl phosphite, 90+% - Phosphorous acid dibenzyl ester - Dibenzylphosphonate - L09858 - Alfa Aesar

L09858 Dibenzyl phosphite, 90+%

Codice CAS
17176-77-1
Sinonimi
Phosphorous acid dibenzyl ester
Dibenzylphosphonate

Dimensioni Prezzo ($) Quantità Disponibilità
5g 32,60
25g 96,10
100g 243,00
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Dibenzyl phosphite, 90+%

MDL
MFCD00004774
EINECS
241-226-1

Proprietà chimiche

Formula
C14H15O3P
Peso formula
262.25
Punto di ebollizione
110-120°/0.1mm
Punto di infiammabilità
>110°(230°F)
Densità
1.187
Indice di rifrazione
1.5540
Sensibilità
Moisture Sensitive
Solubilità
Soluble in DMSO, Methanol. Reacts with water.

Applicazioni

Dibenzyl phosphite is used for the phosphorylation of phenols involves reaction in the presence of N-ethyldiisopropylamine and DMAP to give the dibenzyl phenyl phosphate. It is used in the preparation of phenylalkylphosphonamidates which are then used as probes for a hydrophobic binding register in prostate-specific membrane antigen.

Note

Store at 4°C. Moisture Sensitive. Incompatible with moisture and oxidizing agents. Store under dry inert gas. Store away from oxidizing agents.

Letteratura

Lee J. Silverberg; John L. Dillon; Purushotham Vemishetti. A simple, rapid and efficient protocol for the selective phosphorylation of phenols with dibenzyl phosphite.Tetrahedron Letters.1996, 37 771-774.

Yu-Pei Cheng; Hui-Ting Chen; Chun-Cheng Lin. A convenient and highly stereoselective approach for α-galactosylation performed by galactopyranosyl dibenzyl phosphite with remote participating groups.Tetrahedron Letters.2002, 43 7721-7723.

A selective method for the phosphorylation of phenols involves reaction in the presence of N-ethyldiisopropylamine and DMAP to give the dibenzyl phenyl phosphate: Tetrahedron Lett., 37, 771 (1996).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H317

Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P362-P363-P321-P332+P313-P333+P313-P337+P313-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Wash contaminated clothing before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If skin irritation or rash occurs: If eye irritation persists: Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,3014
Beilstein
1982794
Codice tariffe armonizzato
2920.90
TSCA
No

Raccomandato

  • A10173

    Trifluoromethanesulfonic acid, 98+%
  • A10348

    Benzaldehyde, 99+%
  • A11801

    N-Ethyldiisopropylamine, 99%
  • H51715

    4-(Dimethylamino)pyridine, 99%, prilled
  • 13431

    Sodium hydride, 57-63% oil dispersion

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