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1-Bromo-1-chloro-2,2,2-trifluoroethane has been used in a study that combined molecular simulations with free energy simulations to study solvation of halothane in polarizable water and methanol. It is also used in a study to investigate the interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor. In an effect believed to be independent of anesthesia, halothane inhibits synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.
S Bourgoin; J P Ternaux; A Boireau; F Héry; M Hamon. Effects of halothane and nitrous oxide anesthesia on 5-HT turn-over in the rat brain.Naunyn-Schmiedebergs Archives of Pharmacology.1975, 288 (2-3), 109-121.
Travis J A Craddock; Marc St George; Holly Freedman; Khaled H Barakat; Sambasivarao Damaraju; Stuart Hameroff; Jack A Tuszynski. Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesia.PLoS ONE.2012, 7 (6), e37251.
Dichiarazioni di rischio (UE): H318-H341
Causes serious eye damage. Suspected of causing genetic defects.
Dichiarazioni precauzionali: P260-P201-P280i-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.