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2',3'-Dideoxycytidine in cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV reverse transcriptase (Ki = 51 nM). It incorporates into viral DNA where it terminates chain elongation when the missing hydroxyl group is encountered. It is also is used as a DNA chain-terminating nucleotide for DNA sequencing methods based on the Sanger chain-termination method.
E.Ullyatt; B.C.Liang. 2',3'-Dideoxycytidine is a potent inducer of apoptosis in glioblastoma cells. Anticancer Research. 1998, 18, (3A),1859-1863
C.H.Chen; Y.C.Cheng. Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine. The Journal of Biological Chemistry. 1989, 264, (20),11934-11937
Dichiarazioni di rischio (UE): H351-H361
Suspected of causing cancer. Suspected of damaging fertility or the unborn child.
Dichiarazioni precauzionali: P201-P280-P202-P308+P313-P405-P501a
Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.