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3554-74-3 - 3-Hydroxy-1-methylpiperidine, 98% - 1-Methyl-3-piperidinol - L10829 - Alfa Aesar

L10829 3-Hydroxy-1-methylpiperidine, 98%

Codice CAS
3554-74-3
Sinonimi
1-Methyl-3-piperidinol

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3-Hydroxy-1-methylpiperidine, 98%

MDL
MFCD00006495
EINECS
222-609-2

Proprietà chimiche

Formula
C6H13NO
Peso formula
115.18
Punto di ebollizione
76-78°/11mm
Punto di infiammabilità
70°(158°F)
Densità
0.999
Indice di rifrazione
1.4740
Solubilità
Fully misicible in water.

Applicazioni

Reactant for Optimization of Novobiocin scaffold to produce antitumor agents, Formation of carbamates and N-alkylimidazoles. Reactant for synthesis of Pyridine derivatives as CDK5 inhibitors Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors, Amino phosphite ligands, Mexiletine enantiomers by nucleophilic aromatic substitution.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Letteratura

Huiping Zhao et. al. Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents.. Journal of medicinal and pharmaceutical chemistry,. 2007, 54 (11), 3839-3853.

Matthew R. Kaller et. al. Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19 (23), 6591-6594.

The Na derivative can be used in combination with Ni(OAc) 2 /NaH for desufurization of thioethers, showing dramatic rate enhancement compared with other systems: Tetrahedron Lett ., 39, 8987 (1998).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
103017
Codice tariffe armonizzato
2933.39
TSCA
Yes

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