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69304-37-6 - 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97% - L11171 - Alfa Aesar

L11171 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97%

Codice CAS
69304-37-6
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1g 43,41
5g 173,04
25g 552,08
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1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97%

MDL
MFCD00009655
EINECS
000-000-0

Proprietà chimiche

Formula
C12H28Cl2OSi2
Peso formula
315.43
Punto di ebollizione
69-70°/0.5mm
Punto di infiammabilità
>110°(230°F)
Densità
0.986
Indice di rifrazione
1.4540
Sensibilità
Moisture Sensitive
Solubilità
Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane.

Applicazioni

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is a silylating reagent used for simultaneous protection of 3'- and 5'-hydroxy functions of ribonucleosides. It is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. It is also employed in the formation of ribavirin chemical delivery systems. Further, it serves as a protecting group reagent for open-chain polyhydroxy compounds. In addition to this, it is involved in the preparation of cyclic bridged peptides.

Note

Incompatible with strong oxidizing agents and water.

Letteratura

Reagent for the protection of diols, including carbohydrate-type molecules, as their 1,3-(1,1,3,3-tetraisopropyldisiloxanylidene) (TIPDS) derivatives, formed in the presence of imidazole: J. Chem. Res. Synop., 24 (1979); J. Org. Chem., 50, 1651 (1985), or pyridine-DMF: Tetrahedron, 41, 4545, 4557 (1985). The high steric demand of the TIPDS group enables discrimination between primary and secondary OH. It is readily cleaved by F- (e.g. TBAF in THF) or by aqueous acid or base. See Appendix 4.

Osawa, T.; Hari, Y.; Dohi, M.; Matsuda, Y.; Obika, S. Synthesis and Properties of the 5-Methyluridine Derivative of 3,4-Dihydro-2H-pyran-Bridged Nucleic Acid (DpNA). J. Org. Chem. 2015, 80 (21), 10474-10481.

Clobes, C.; Jerabek, P.; Nußbruch, I.; Frenking, G.; von Hänisch, C. Stepwise Synthesis of Siloxane-Substituted Oligoarsanes and Structural Investigation of Alkaline Earth Metal Derivatives. Eur. J. Inorg. Chem. 2015, 2015 (20), 3264-3273.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1934216
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2931.90
TSCA
No

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