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98-79-3 - (S)-(-)-2-Pyrrolidinone-5-carboxylic acid, 98+% - L-Pyroglutamic acid - H-Pyr-OH - L11711 - Alfa Aesar

L11711 (S)-(-)-2-Pyrrolidinone-5-carboxylic acid, 98+%

Codice CAS
98-79-3
Sinonimi
L-Pyroglutamic acid
H-Pyr-OH

Dimensioni Prezzo ($) Quantità Disponibilità
25g 22,20
100g 52,70
500g 199,00
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(S)-(-)-2-Pyrrolidinone-5-carboxylic acid, 98+%

MDL
MFCD00005272
EINECS
202-700-3

Proprietà chimiche

Formula
C5H7NO3
Peso formula
129.12
Punto di fusione
158-162°
Solubilità
Soluble in water (10-15% at 20°C), alcohol, acetone, dimethyl sufoxide and methanol.

Applicazioni

(S)-(-)-2-Pyrrolidinone-5-carboxylic acid is used as a building block for pharmaceuticals and asymmetric synthesis. It Is also used as a resolving agent for chiral bases and in an efficient synthesis of quinolizidine and indolizidine alkaloids.

Note

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Letteratura

Liang Wang.; Xiangju Meng.; Bin Wang.; Wenyang Chi.; Feng-Shou Xiao. Pyrrolidone-modified SBA-15 supported Au nanoparticles with superior catalytic properties in aerobic oxidation of alcohols. Chem. Commun. 2010, 46 (27), 5003-5005.

Liang Wang.; Hong Wang.; Prokop Hapala.; Longfeng Zhu.; Limin Renb, Xiangju Meng.; James P. Lewis.; Feng-Shou Xiao. Superior catalytic properties in aerobic oxidation of olefins over Au nanoparticles on pyrrolidone-modified SBA-15. Journal of Catalysis. 2011, 281 (1), 30-393.

Resolving agent for chiral bases: Helv. Chim. Acta, 41, 181 (1958). Versatile chiral starting material:

Reduction to the alcohol followed by reaction with benzaldehyde gives a bicyclic lactam which is a useful chiral synthon: J. Org. Chem., 51, 3140 (1986); Tetrahedron Lett., 32, 1379 (1991):

For use in an efficient synthesis of quinolizidine and indolizidine alkaloids, see: J. Org. Chem., 60, 717 (1995).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,8001
Beilstein
82132
Codice tariffe armonizzato
2933.79
TSCA
Yes
RTECS
TW3710000

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