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298-93-1 - Thiazolyl Blue tetrazolium bromide, 98% - 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide - MTT - L11939 - Alfa Aesar

L11939 Thiazolyl Blue tetrazolium bromide, 98%

Codice CAS
298-93-1
Sinonimi
3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide
MTT

Dimensioni Prezzo ($) Quantità Disponibilità
1g 43,20
5g 132,00
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Thiazolyl Blue tetrazolium bromide, 98%

MDL
MFCD00011964
EINECS
206-069-5

Proprietà chimiche

Formula
C18H16BrN5S
Peso formula
414.33
Punto di fusione
ca 195° dec.
Sensibilità
Light, Air & Moisture Sensitive
Solubilità
Soluble in water, ethanol, 2-methoxyethanol and phosphate buffered saline.

Applicazioni

Used in measurement of cell proliferation. Produces a yellowish solution that is converted to dark blue, water-insoluble MTT formazan by mitochondrial dehydrogenases of living cells.Thiazolyl Blue tetrazolium bromide is a dye used in measurement of cell proliferation. It is used as a direct indicator of cytotoxicity (such as for screening cancer drugs) and apoptosis. As an electron acceptor, it is utilized for studying nicotinamide adenine dinucleotide phosphate (NADP)-dependent dehydrogenases.

Note

Light, air and moisture sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Letteratura

Ma, W.; Xu, A.; Ying, J.; Li, B.; Jin, Y. Biodegradable Core-Shell Copolymer-Phospholipid Nanoparticles for Combination Chemotherapy: An In Vitro Study. J. Biomed. Nanotechnol. 2015, 11 (7), 1193-1200.

Wei, D.; Chen, T.; Yan, M.; Zhao, W.; Li, F.; Cheng, W.; Yuan, L. Synthesis, characterization, antioxidant activity and neuroprotective effects of selenium polysaccharide from Radix hedysari. Carbohydr. Polym. 2015, 125, 161-168.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
3825277
Codice tariffe armonizzato
2934.99
TSCA
Yes
RTECS
XF8060000

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