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L12919 2,3-Dimethylmaleic anhydride, 97%

Codice CAS
766-39-2
Sinonimi
3,4-Dimethyl-2,5-furandione

Stock No. Dimensioni Prezzo ($) Quantità Disponibilità
L12919-06 5g 60,90
L12919-14 25g 239,00
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2,3-Dimethylmaleic anhydride, 97%

MDL
MFCD00005523
EINECS
212-165-8

Proprietà chimiche

Formula
C6H6O3
Peso formula
126.11
Punto di fusione
93-96°
Punto di ebollizione
222-223°
Storage & Sensitivity
Moisture Sensitive. Store under Nitrogen. Ambient temperatures.
Solubilità
Soluble in ethanol, ether and chloroform. Slightly soluble in water.

Applicazioni

2,3-Dimethylmaleic anhydride acts as a reagent in the preparation of maleimides. It is also employed as an amino group protecting agent for superoxide dismutase. Further, it serves as a reactant in the dissociation of ribosomal proteins. In addition to this, it is used in the preparation of dimethylmaleic acid dimethyl ester.

Note

Moisture sensitive. Incompatible with strong oxidizing agents, strong acids and strong bases.

Letteratura

Does not undergo Diels-Alder reactions with furan, but does react with 1,3-Diphenyl­isobenzofuran, L00101, to give benzocantharadin: J. Org. Chem., 47, 4011 (1982).

The use of the dimethylmaleoyl (DMM) group has been investigated for amino group protection in oligosaccharide synthesis. The DMM group is introduced using triethylamine as base. It promotes ß -linkage by neighboring group participation and is stable to acids and non-nucleophilic bases. Cleavage can be brought about by treatment with dilute aqueous NaOH: Eur. J. Org. Chem., 2305 (1998).

Zhang, M. H.; Gu, Z. P.; Zhang, X.; Fan, M. M. pH-sensitive ternary nanoparticles for nonviral gene delivery. RSC Adv. 2015, 5 (55), 44291-44298.

Yang, K.; Feng, L.; Liu, Z. The advancing uses of nano-graphene in drug delivery. Expert Opin. Drug Deliv. 2015, 12 (4), 601-612.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H318

Harmful if swallowed. Causes serious eye damage.

Dichiarazioni precauzionali: P280i-P264-P305+P351+P338-P310a-P301+P312a-P501a

Wear eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
112044
Codice tariffe armonizzato
2917.19
TSCA
Yes
RTECS
ON4025000

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