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143-33-9 - Sodium cyanide, granules, 98% - L13278 - Alfa Aesar

L13278 Sodium cyanide, granules, 98%

Codice CAS
143-33-9
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
50g 24,00
250g 30,80
1000g 59,70
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Sodium cyanide, granules, 98%

MDL
MFCD00003523
EINECS
205-599-4

Proprietà chimiche

Formula
CNNa
Peso formula
49.01
Punto di fusione
563°
Punto di ebollizione
ca 1500°
Densità
1.61
Solubilità
Soluble in water, ammonia, methanol and ethanol. Slightly soluble in dimethylformamide. Insoluble in dimethylsulphoxide.

Applicazioni

Sodium cyanide is used as a starting material for the preparation of Reissert compounds and cyanogen bromide, cyanuric chloride and cyanogen chloride. It acts as a catalyst for the aminolysis of esters to primary amides. Furthermore, it is used for fumigation, electroplating, extracting gold and silver in mining industry. In organic synthesis, it is involved in the cyanation reaction of alkyl halides under phase transfer conditions.

Note

Hygroscopic. Do not store near acids. Incompatible with strong oxidizing agents and carbon dioxide.

Letteratura

Cyanations of alkyl halides are often carried out most conveniently under phase-transfer conditions: Synth. Commun., 6, 193 (1976); see: E. V. Dehmlow and S. S. Dehmlow, Phase-Transfer Catalysis, 3rd ed., VCH, N.Y. (1993), for further extensive examples. DMSO is also a good solvent for these reactions: J. Org. Chem., 25, 257, 877 (1960).

For formation of Reissert compounds, see Quinoline, A11545.

Mild catalyst for the aminolysis of esters to primary amides: J. Org. Chem., 52, 2033 (1987).

For generation of cyanogen bromide by reaction with bromine, see: Org. Synth. Coll ., 7, 435 (1990).

See also Potassium cyanide, L13273.

Murahashi, S. I.; Nakae, T.; Terai, H.; Komiya, N. Ruthenium-Catalyzed Oxidative Cyanation of Tertiary Amines with Molecular Oxygen or Hydrogen Peroxide and Sodium Cyanide: sp3 C-H Bond Activation and Carbon- Carbon Bond Formation. J. Am. Chem. Soc. 2008, 130 (33), 11005-11012.

Singhal, S.; Jain, S. L.; Sain, B. An efficient aerobic oxidative cyanation of tertiary amines with sodium cyanide using vanadium based systems as catalysts. Chem. Commun. 2009, 17, 2371-2372.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H290-H300-H310-H330-H372

May be corrosive to metals. Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes damage to organs through prolonged or repeated exposure.

Dichiarazioni precauzionali: P301+P310a-P304+P340-P320-P330-P405-P501a

IF SWALLOWED: IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,8605
Beilstein
3587243
Classe di rischio
6.1
Gruppo di imballaggio
I
Codice tariffe armonizzato
2837.11
TSCA
Yes
RTECS
VZ7525000

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