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1445-45-0 - Trimethyl orthoacetate, 98% - 1,1,1-Trimethoxyethane - L13369 - Alfa Aesar

L13369 Trimethyl orthoacetate, 98%

Codice CAS
1445-45-0
Sinonimi
1,1,1-Trimethoxyethane

Dimensioni Prezzo ($) Quantità Disponibilità
50ml 33,30
250ml 88,00
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Trimethyl orthoacetate, 98%

MDL
MFCD00008477
EINECS
215-892-9

Proprietà chimiche

Formula
C5H12O3
Peso formula
120.15
Punto di ebollizione
107-109°
Punto di infiammabilità
16°(60°F)
Densità
0.956
Indice di rifrazione
1.3890
Sensibilità
Moisture Sensitive
Solubilità
It hydrolyzes in water.

Applicazioni

Trimethyl orthoacetate is used as a diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange. It is mainly used as the chemical intermediates of the medicine. Some of the other applications includes it is mainly used as chemical intermediate of pharmaceutical and agricultural chemicals, used for compound medical intermediates of vitamin B1, vitamin A1 and sulfanilamide organism, used for dye and spices industry, Medicine, agricultural chemicals, paint additives.

Note

Moisture Sensitive. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

Letteratura

HPM Fromageot.; BE Griffin.; CB Reese.; JE Sulston. The synthesis of oligoribonucleotides—III: Monoacrylation of ribonucleosides and derivativesvia orthoester exchange. Tetrahedron. 1967, 23,(5), 2315-2331.

T Yoshino.; S Imori.; H Togo. Efficient esterification of carboxylic acids and phosphonic acids with trialkyl orthoacetate in ionic liquid. Tetrahedron. 2006, 62,(6), 1309-1317.

Diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange; see, e.g.: J. Am. Chem. Soc., 95, 278 (1973). See also Triethyl­ orthoacetate, L06004.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H315-H319-H335

Highly flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1098338
Classe di rischio
3
Gruppo di imballaggio
II
Codice tariffe armonizzato
2915.90
TSCA
Yes

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