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3-Bromopentane is a glass forming liquid used in the preparation of 2-(1-ethyl-propoxy)-isoindole-1,3-dione. Further, it is employed in organic synthesis.
Can be used to introduce the 3-pentyl (Pen) group for protection of the phenolic OH group of tyrosine residues in peptide synthesis. See Appendix 6. The Pen group can be introduced in the presence of NaH in DMF. In comparison with other common OH protecting groups, Pen is relatively stable to 50% TFA in dichloromethane and completely stable to 20% piperidine in DMF, but can be cleaved with HF in the presence of a cation scavenger, e.g. anisole or p-cresol: Terahedron Lett., 39, 7117 (1998).
Belter, R. K. Addition reactions of organometallic reagents to nitrogen trifluoride and enhanced alkyl-alkyl coupling by NF3. J. Fluorine Chem. 2015, 175, 110-113.
Sakaguchi, T.; Nakano, T.; Tominaga, S.; Hashimoto, T. Polycondensation of di- and tetrasubstituted dibromobenzenes for synthesis of poly(p-phenylene)s having alkoxy groups and gas permeability of membranes. Polym. J. 2015, 47, 362-368.
Dichiarazioni di rischio (UE): H225-H315-H319-H335
Highly flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P260-P201-P280g-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.