Autorizzo l’utilizzo di cookies.

Accetto Utilizziamo cookies per migliorare il nostro servizio e realizzare statistiche. Questa funzione puó essere disattivata cambiando la configurazione del browser. Continuando a navigare senza modificare questi parametri, consideriamo che l’uso di cookies sia accettato

L14143 2,6-Di-tert-butyl-4-methylpyridine, 97%

Codice CAS
38222-83-2
Sinonimi
DTBMP

Stock No. Dimensioni Prezzo ($) Quantità Disponibilità
L14143-03 1g 32,40
L14143-06 5g 113,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

2,6-Di-tert-butyl-4-methylpyridine, 97%

MDL
MFCD00006305
EINECS
253-834-4

Proprietà chimiche

Formula
C14H23N
Peso formula
205.35
Punto di fusione
30-35°
Punto di ebollizione
232-234°
Punto di infiammabilità
83°(181°F)
Indice di rifrazione
1.4765
Storage & Sensitivity
Keep Cold. Air Sensitive. Light Sensitive. Store under Nitrogen.
Solubilità
Sparingly soluble in water. Soluble in ethanol, acetic acid and diethyl ether.

Applicazioni

2,6-Di-tert-butyl-4-methylpyridine is used for the generation of enol triflates from ketones using trifluoromethanesulfonic anhydride. It is also used in the synthesis of 1,2-dihydro-2-silanaphthalene derivatives, as base in PtCl4-catalyzed cyclization reactions of homopropargyl azide derivatives and in diastereoselective synthesis of β-thiomannopyranosides.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature is 2 - 8°C. Store under inert gas. It is sensitive to air and light.

Letteratura

D Crich.; H Li. Direct stereoselective synthesis of beta-thiomannosides. Journal of Organic Chemistry. 2000, 65 (3), 801-805.

Hidekazu Arii.; Takashi Kurihara.; Kunio Mochida.; Takayuki Kawashima.Silylium ion-promoted dehydrogenative cyclization: synthesis of silicon-containing compounds derived from alkynes. Chemical Communications. 2014, 50 (50), 6649-6652.

Sterically-hindered, non-nucleophilic base.

Recommended base for the generation of enol triflates from ketones using Trifluoromethanesulfonic anhydride, A11767: J. Org. Chem., 54, 2886 (1989). For examples, see: Org. Synth. Coll., 8, 97, 126 (1993). For comparison with other hindered bases in peptide coupling reactions, see: J. Org. Chem., 61, 2460 (1996). See also Appendix 6.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
130503
Codice tariffe armonizzato
2933.39
TSCA
No

Raccomandato

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio