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4136-95-2 - 2,4,6-Trichlorobenzoyl chloride, 98% - L14159 - Alfa Aesar

L14159 2,4,6-Trichlorobenzoyl chloride, 98%

Codice CAS
4136-95-2
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
5g 44,30
25g 193,00
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2,4,6-Trichlorobenzoyl chloride, 98%

MDL
MFCD00075323

Proprietà chimiche

Formula
C7H2Cl4O
Peso formula
243.91
Punto di ebollizione
107-108°/6mm
Punto di infiammabilità
>110°(230°F)
Densità
1.561
Indice di rifrazione
1.5750
Sensibilità
Moisture Sensitive
Solubilità
Reacts with water.

Applicazioni

2,4,6-Trichlorobenzoyl chloride is used in the preparation of γ-lactone and δ-lactone, aliphatic aromatic anhydrides, required for the synthesis of amphiphilic hyaluronan, mixed anhydride, required for the synthesis of angelate esters, synthesis of both spongistatin 1 and spongistatin 2 and large-ring lactones in high yields.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. It is sensitive to moisture. Incompatible with strong bases and strong oxidizing agents.

Letteratura

Gloria Huerta-Angeles.; Martin Bobek.; Eva P?íkopová.; Daniela Šmejkalová.; Vladimír Velebný. Novel synthetic method for the preparation of amphiphilic hyaluronan by means of aliphatic aromatic anhydrides. .Carbohydrate Polymers 2014, 111 883-891.

Machiko Ono.; Keisuke Kato.; Hiroyuki Akita. Synthesis of γ- and δ-lactone natural products by employing a trans-cis isomerization/lactonization strategy. Chemical & Pharmaceutical Bulletin. 2013, 61 (4), 464-470.

Reagent, introduced by Yamaguchi, which forms mixed anhydrides with acids, useful in the synthesis of esters: Bull. Chem. Soc. Jpn., 52, 1989 (1979), or lactones including macrolides: Chem. Lett., 1021 (1979). Superior to mesitylenesulfonyl chloride for macrolactonization, which has been achieved in the presence of DMAP without the need for high dilution: J. Org. Chem., 55, 7 (1990); Tetrahedron Lett., 31, 6367 (1990).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
2050280
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2916.39
TSCA
No

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