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N-Fluoropyridinium trifluoromethanesulfonate is used as a reagent for electrophilic fluorination and for a review of electrophilic N-F fluorinating agents. It is also used as a reactant for Pd-catalyzed arylation reactions and as a fluorination agent.
Xisheng Wang.; Dasheng Leow.; Jin-Quan Yu. Pd(II)-catalyzed para-selective C-H arylation of monosubstituted arenes. Journal of the American Chemical Society. 2011, 133 (35), 13864-13867
Teruo Umemoto.; Kosuke Kawada.; Kyoichi Tomita. N-fluoropyridinium triflate and its derivatives: Useful fluorinating agents. Tetrahedron Letters. 1986, 27 (37), 4465-4468
Reagent for electrophilic fluorination:
Alkyl or silyl enol ethers give ɑ-fluoro ketones: Tetrahedron Lett., 27, 3271, 4465 (1986); Org. Synth. Coll., 8, 286 (1993). For regioselective mono-ɑ-fluorination of steroids bearing several silyl enol ether groups, see: J. Am. Chem. Soc., 112, 8563 (1990).
For a review of electrophilic N-F fluorinating agents, see: Chem. Rev., 96, 1737 (1996).
Dichiarazioni di rischio (UE): H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Dichiarazioni precauzionali: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.