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112022-83-0 - (R)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene - (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole - L14582 - Alfa Aesar

L14582 (R)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene

Codice CAS
112022-83-0
Sinonimi
(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

Dimensioni Prezzo ($) Quantità Disponibilità
1ml 35,90
5ml 75,00
25ml 301,00
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(R)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene

MDL
MFCD00078440

Proprietà chimiche

Formula
C18H20BNO
Peso formula
277.17
Punto di infiammabilità
4°(39°F)
Densità
0.925
Sensibilità
Air & Moisture Sensitive
Solubilità
Not miscible or difficult to mix in water.

Applicazioni

(R)-2-Methyl-CBS-oxazaborolidine is used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2 symmetrical ferrocenyl diols, and propargyl alcohols. It is also used in a desymmetrizing reduction leading to (S)-4-hydroxycyclohexenone. It is useful in the production of stereospecific motifs such as α-hydroxy acids, α-amino acids, symmetrical ferrocenyl diols and propargyl alcohols.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store under inert gas. It is sensitive to moisture and air. Incompatible with oxidizing agents.

Letteratura

Parker, K. A.; Ledeboer, M. W. Asymmetric Reduction. A Convenient Method for the Reduction of Alkynyl Ketones. J. Org. Chem. 1996, 61/span> 3214.

Marcel Hoogenraad.; Guido M Klaus.; Niels Elders.; Simone M Hooijschuur.; Ben McKay.; Alan A Smith.; Eric W.P Damen. Oxazaborolidine mediated asymmetric ketone reduction: prediction of enantiomeric excess based on catalyst structure. Tetrahedron: Asymmetry. 2004, 15 (3), 519-523.

Anhydrous catalyst for CBS reduction reaction. For further information, see (S)-2-Methyl-CBS-oxazaborolidine monohydrate, L09219.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H302-H333-H315-H361-H336-H373-H304

Highly flammable liquid and vapour. Harmful if swallowed. May be harmful if inhaled. Causes skin irritation. Suspected of damaging fertility or the unborn child. May cause drowsiness or dizziness. May cause damage to organs through prolonged or repeated exposure. May be fatal if swallowed and enters airways.

Dichiarazioni precauzionali: P210-P260-P301+P310a-P303+P361+P353-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. IF SWALLOWED: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Classe di rischio
3
Gruppo di imballaggio
II
Codice tariffe armonizzato
2934.99
TSCA
No

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