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4487-59-6 - 2-Bromo-5-nitropyridine, 98+% - L15661 - Alfa Aesar

L15661 2-Bromo-5-nitropyridine, 98+%

Codice CAS
4487-59-6
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1g 24,60
5g 76,10
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2-Bromo-5-nitropyridine, 98+%

MDL
MFCD00006222
EINECS
224-777-2

Proprietà chimiche

Formula
C5H3BrN2O2
Peso formula
203.00
Punto di fusione
136-140°
Punto di ebollizione
145-147°/10mm
Solubilità
Insoluble in water.

Applicazioni

2-Bromo-5-nitropyridine was used in preparation of boc-protected (piperazin-1-ylmethyl)biaryls via microwave-mediated Suzuki-Miyaura coupling with (boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters. It was also used in the synthesis of 2-pyridyl analogs. Substituted 5-nitro-2-ethynylpyridines were synthesized by the Sonogashira reaction of 2-bromo-5-5-nitropyridine with terminal acetylenes.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Letteratura

Spencer J, et al. Synthesis of a (piperazin-1-ylmethyl) biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings.. Tetrahedron Lett. 201152 (31), 3963-68.

Hashim Motiwala et. al. Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors. Bioorganic & Medicinal Chemistry Letters, . 2011, 21 (19), 5812-5817.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H312-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P260-P201-P280h-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
120901
Codice tariffe armonizzato
2933.39
TSCA
No

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