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Allylboronic acid pinacol ester reacts with carboxylic acids, in the presence of tri-n-butyltin hydride, to give homoallylic alcohols in good yield. Homoallylic alcohols can also be formed by allylboration of aldehydes. It is a reagent used for palladium-catalyzed Suzuki-Miyaura cross-coupling reactions and olefin metathesis, intermolecular radical additions, allylboration of aldehydes catalyzed by chiral spirobiindane diol (SPINOL) based phosphoric acids, cobalt-catalyzed regioselective hydrovinylation of dienes with alkenes, nucleic acid-templated energy transfer leading to a photorelease reaction and stereoselective indium-catalyzed Hosomi-Sakurai reactions.
Sambasivarao Kotha.; Arjun S Chavan.; Mobin Shaikh. Diversity-oriented approach to macrocyclic cyclophane derivatives by Suzuki-Miyaura cross-coupling and olefin metathesis as key steps. Journal of Organic Chemistry. 2012, 77 (1), 482-489.
Nicolas Charrier, Zhibo Liu, Samir Z Zard. Desulfonylative radical ring closure onto aromatics. A modular route to benzazepin-2-ones and 5-arylpiperidin-2-ones. Organic Letters. 2012, 14 (8), 2018-2021.
Reacts with carboxylic acids, in the presence of tri-n-butyltin hydride, to give homoallylic alcohols in good yield: Synthesis, 1573 (2001):
Homoallylic alcohols can also be formed by allylboration of aldehydes; the reaction has been found to be accelerated by Lewis acids, e.g. AlCl3 or Sc(OTf)3: J. Am. Chem. Soc., 124, 12414 (2002).
Dichiarazioni di rischio (UE): H226
Flammable liquid and vapour.
Dichiarazioni precauzionali: P260-P201-P280a-P304+P340-P405-P501a
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