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50-91-9 - 5-Fluoro-2'-deoxyuridine, 98+% - 2'-Deoxy-5-fluorouridine - Floxuridine - L16497 - Alfa Aesar

L16497 5-Fluoro-2'-deoxyuridine, 98+%

Codice CAS
50-91-9
Sinonimi
2'-Deoxy-5-fluorouridine
Floxuridine

Dimensioni Prezzo ($) Quantità Disponibilità
100mg 80,00
500mg 264,00
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5-Fluoro-2'-deoxyuridine, 98+%

MDL
MFCD00006530
EINECS
200-072-5

Proprietà chimiche

Formula
C9H11FN2O5
Peso formula
246.20
Punto di fusione
148-151°
Solubilità
Soluble in water, alcohol, isopropyl alcohol, methanol, aqueous buffers, acetone, dimethyl sulfoxide, and ethanol. Insoluble in ether, benzene and chloroform.

Applicazioni

5-Fluoro-2'-deoxyuridine acts as an antiviral and antineoplastic agent. It is also employed for renal function diagnosis. Further, it is used as an experimental anticancer agent, which shows activity against a variety of malignant neoplasms. It is also used as an inhibitor of thymidylate synthetase and DNA synthesis. In addition to this, it plays an important role in the treatment of colorectal cancer.

Note

Store in a cool place.Incompatible with strong oxidizing agents and strong bases.

Letteratura

Rooney, J. P.; Luz, A. L.; Gonzalez-Hunt, C. P.; Bodhicharla, R.; Ryde, I. T.; Anbalagan, C.; Meyer, J. N. Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans. Exp. Gerontol. 2014, 56, 69-76.

Kruspe, S.; Hahn, U. An Aptamer Intrinsically Comprising 5-Fluoro-2'-deoxyuridine for Targeted Chemotherapy. Mol. BioSyst. 2014, 53 (39), 10541-10544.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H341-H360

Harmful if swallowed. Suspected of causing genetic defects. May damage fertility or the unborn child.

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,4112
Beilstein
2645818
Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2934.99
TSCA
No
RTECS
YU7535000

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