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27784-76-5 - tert-Butyl diethylphosphonoacetate, 95% - Diethylphosphonoacetic acid tert butyl ester - L17651 - Alfa Aesar

L17651 tert-Butyl diethylphosphonoacetate, 95%

Codice CAS
27784-76-5
Sinonimi
Diethylphosphonoacetic acid tert butyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
1g 30,70
5g 89,70
25g 316,00
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tert-Butyl diethylphosphonoacetate, 95%

MDL
MFCD00075414
EINECS
000-000-0

Proprietà chimiche

Formula
C10H21O5P
Peso formula
252.25
Punto di ebollizione
100-103°/1.5mm
Punto di infiammabilità
>110°(230°F)
Densità
1.074
Indice di rifrazione
1.4310
Solubilità
Not miscible or difficult to mix in water.

Applicazioni

tert-Butyl diethylphosphonoacetate is used as a reactant for preparation of hydroxymethylated dihydroxyvitamin D3 analogs via Wittig-Horner approach, as potential antitumor agents, synthesis of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat 3) and bicyclic triaminophosphine-promoted stereoselective synthesis of a,ß-unsaturated esters, fluorides, and nitriles from aldehydes and ketones using Wadsworth-Emmons phosphonates

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.

Letteratura

Pijus K Mandal.; Fengqin Gao.; Zhen Lu.; Zhiyong Ren.; Rajagopal Ramesh.; J Sanderson Birtwistle.; Kumaralal K Kaluarachchi.; Xiaomin Chen.; Robert C Bast.; Warren S Liao.; John S McMurray. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 . Journal of medicinal and pharmaceutical chemistry. 2011, 54 (10), 3549-3563.

Maria A Regueira.; Shaonly Samanta.; Peter J Malloy.; Paloma Ordonez-Moran.; Diana Resende.; Fredy Sussman.; Alberto Munoz.; Antonio Mourino.; David Feldman.; Mercedes Torneiro. Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D(3) analogues hydroxymethylated at C-26. Langmuir. 2011, 54 (11), 3950-3962.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Dichiarazioni precauzionali: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Altri riferimenti

Beilstein
2050126
Codice tariffe armonizzato
2931.90
TSCA
No

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