Autorizzo l’utilizzo di cookies.

Accetto Utilizziamo cookies per migliorare il nostro servizio e realizzare statistiche. Questa funzione puó essere disattivata cambiando la configurazione del browser. Continuando a navigare senza modificare questi parametri, consideriamo che l’uso di cookies sia accettato

27784-76-5 - tert-Butyl diethylphosphonoacetate, 95% - Diethylphosphonoacetic acid tert butyl ester - L17651 - Alfa Aesar

L17651 tert-Butyl diethylphosphonoacetate, 95%

Codice CAS
27784-76-5
Sinonimi
Diethylphosphonoacetic acid tert butyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
1g 30,70
5g 89,70
25g 316,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

tert-Butyl diethylphosphonoacetate, 95%

MDL
MFCD00075414
EINECS
000-000-0

Proprietà chimiche

Formula
C10H21O5P
Peso formula
252.25
Punto di ebollizione
100-103°/1.5mm
Punto di infiammabilità
>110°(230°F)
Densità
1.074
Indice di rifrazione
1.4310
Solubilità
Not miscible or difficult to mix in water.

Applicazioni

tert-Butyl diethylphosphonoacetate is used as a reactant for preparation of hydroxymethylated dihydroxyvitamin D3 analogs via Wittig-Horner approach, as potential antitumor agents, synthesis of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat 3) and bicyclic triaminophosphine-promoted stereoselective synthesis of a,ß-unsaturated esters, fluorides, and nitriles from aldehydes and ketones using Wadsworth-Emmons phosphonates

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.

Letteratura

Pijus K Mandal.; Fengqin Gao.; Zhen Lu.; Zhiyong Ren.; Rajagopal Ramesh.; J Sanderson Birtwistle.; Kumaralal K Kaluarachchi.; Xiaomin Chen.; Robert C Bast.; Warren S Liao.; John S McMurray. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 . Journal of medicinal and pharmaceutical chemistry. 2011, 54 (10), 3549-3563.

Maria A Regueira.; Shaonly Samanta.; Peter J Malloy.; Paloma Ordonez-Moran.; Diana Resende.; Fredy Sussman.; Alberto Munoz.; Antonio Mourino.; David Feldman.; Mercedes Torneiro. Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D(3) analogues hydroxymethylated at C-26. Langmuir. 2011, 54 (11), 3950-3962.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Dichiarazioni precauzionali: P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313

Wear protective gloves and eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists:

Altri riferimenti

Beilstein
2050126
Codice tariffe armonizzato
2931.39
TSCA
No

Raccomandato

  • A12751

    Phenylselenenyl chloride, 98%
  • A13519

    1,8-Naphthalic anhydride, 97%
  • A13535

    Benzyl bromide, 99%
  • A17444

    Trichloromethyl chloroformate, 98%
  • L19299

    (S)-(-)-N-Benzyl-1-phenylethylamine, ChiPros 99%, ee 99+%

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio