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19493-44-8 - 1-Chloroisoquinoline, 95% - L17831 - Alfa Aesar

L17831 1-Chloroisoquinoline, 95%

Codice CAS
19493-44-8
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1g 30,90
5g 101,00
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1-Chloroisoquinoline, 95%

MDL
MFCD00024134
EINECS
000-000-0

Proprietà chimiche

Formula
C9H6ClN
Peso formula
163.61
Punto di fusione
33-35°
Punto di ebollizione
105-108°/4mm
Punto di infiammabilità
>110°(230°F)
Solubilità
Insoluble in water.

Applicazioni

The product has been used in a Mn-catalyzed cross-coupling with aryl- and alkylmagnesium halides. It has also been used in a Pd-catalyzed cross-coupling with heteroaryl boronic acids and esters. Furthermore, it has been used in a homocoupling reaction to yield bis-isoquinoline, each enantiomer of which might be very useful as a chiral ligand for asymmetric synthesis. 1-Chloroisoquinone is used in the preparation of new aminoisoquinolinylurea derivatives which show antiproliferative activity against melanoma cell lines. It can also be applied to the control of storage age and stability of unstable boronic acids.

Note

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Letteratura

Kelvin Billingsley and Stephen L Buchwald. Highly efficient monophosphine-based catalyst for the palladium-catalyzed suzuki-miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.J. Am. Chem. Soc.,2007,129(11), 3358-3366.

Chang, et al. Homocoupling of aryl iodides and bromides using a palladium/indium bimetallic system.Synth. Commun.,2005,35(13), 1851-1857.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
2996
Codice tariffe armonizzato
2933.49
TSCA
No

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