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3886-69-9 - (R)-(+)-1-Phenylethylamine, ChiPros 99+%, ee 99+% - D-(+)-alpha-Methylbenzylamine - L19117 - Alfa Aesar

L19117 (R)-(+)-1-Phenylethylamine, ChiPros 99+%, ee 99+%

Codice CAS
3886-69-9
Sinonimi
D-(+)-alpha-Methylbenzylamine

Dimensioni Prezzo ($) Quantità Disponibilità
5g 21,69
25g 50,94
100g 139,05
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(R)-(+)-1-Phenylethylamine, ChiPros 99+%, ee 99+%

MDL
MFCD00064405
EINECS
223-423-4

Proprietà chimiche

Formula
C8H11N
Peso formula
121.18
Punto di fusione
-10°
Punto di ebollizione
187°
Punto di infiammabilità
71°(159°F)
Densità
0.948
Indice di rifrazione
1.5260
Sensibilità
Air Sensitive
Solubilità
Miscible with water and chloroform.

Applicazioni

(R)-(+)-1-Phenylethylamine is used as an intermediate in organic synthesis. It is also used to determine the enantiomeric purity of acids.

Note

Store in a cool place. Air Sensitive. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents and carbon dioxide.

Letteratura

Both enantiomers are widely used resolving agent for chiral acids. They also find extensive use as chiral auxiliaries in asymmetric synthesis:

For use in the enantioselective synthesis of ɑ-amino nitriles and amino acids in the Strecker reaction, see: Chem. Ber., 110, 2098 (1977); J. Org. Chem., 48, 5369 (1983). Similarly, the preformed imines can be reacted with Trimethyl­silyl­ cyanide, A19598: Chem. Lett., 331, 737 (1975). Enantioselective synthesis of cyclohexylamines from 2-alkylcyclohexanones via the imine and reduction: Tetrahedron Lett., 22, 2633 (1981); Chem. Ber., 117, 2076 (1984). Enantioselective synthesis of ɑ-aminoacetals from 1,1-dialkoxy-2-propanones: Synthesis, 608 (1989).

Selivanova, S. V.; Toscano, A.; Abate, C.; Berardi, F.; Müller, A.; Krämer, S. D.; Schibli, R.; Ametamey, S. M. Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging. Nucl. Med. Biol. 2015, 42 (4), 399-405.

Alvarado-Beltrán, I.; Maerten, E.; Toscano, R. A.; López-Cortés, J. G.; Baceiredo, A.; Álvarez-Toledano, C. Enantioselective synthesis of 4-alkenoic acids via Pd-catalyzed allylic alkylation: stereocontrolled construction of gamma and delta-lactones. Tetrahedron: Asymmetry 2015, 26 (15-16), 802-809.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H311-H302-H314-H318-H227

Toxic in contact with skin. Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid.

Dichiarazioni precauzionali: P210-P260-P280-P303+P361+P353-P305+P351+P338-P361-P301+P330+P331-P304+P340-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,6026
Beilstein
2410916
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2921.49
TSCA
Yes

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