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68957-94-8 - 1-Propylphosphonic acid cyclic anhydride, 50+% soln. in DMF - 1-Propanephosphonic acid cyclic anhydride - T3P - L19271 - Alfa Aesar

L19271 1-Propylphosphonic acid cyclic anhydride, 50+% soln. in DMF

Codice CAS
68957-94-8
Sinonimi
1-Propanephosphonic acid cyclic anhydride
T3P

Dimensioni Prezzo ($) Quantità Disponibilità
10g 36,60
50g 152,00
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1-Propylphosphonic acid cyclic anhydride, 50+% soln. in DMF

MDL
MFCD00006583
EINECS
422-210-5

Proprietà chimiche

Formula
C9H21O6P3
Peso formula
318.19
Punto di ebollizione
153°
Punto di infiammabilità
62°(143°F)
Densità
1.090
Indice di rifrazione
1.4505
Sensibilità
Moisture Sensitive
Solubilità
Miscible with dichloromethane, dioxane, terahydrofuran, polar and aprotic organic solvents.

Applicazioni

1-Propylphosphonic acid cyclic anhydride is used in the synthesis of N-acyloxythiazole-2(3H)-thiones. It is also used to promote the synthesis of hydroxamic acids from carboxylic acids. Further, it is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.

Note

Moisture sensitive. Incompatible withstrong oxidizing agents.

Letteratura

T3P is a registered trademark of Archimica.

For use in the synthesis of N-acyloxythiazole-2(3H)-thiones, see: Synlett, 371 (2000).

Augustine, J. K.; Kumar, R.; Bombrun, A.; Mandal, A. B. An efficient catalytic method for the Beckmann rearrangement of ketoximes to amides and aldoximes to nitriles mediated by propylphosphonic anhydride (T3P®). Tetrahedron Lett. 2011, 52 (10), 1074-1077.

Augustine, J. K.; Bombrun, A.; Ramappa, B.; Boodappa, C. An efficient one-pot synthesis of coumarins mediated by propylphosphonic anhydride (T3P) via the Perkin condensation. Tetrahedron Lett. 2012, 53 (33), 4422-4425.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H227-H302-H332-H314-H318-H360

Combustible liquid. Harmful if swallowed. Harmful if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. May damage fertility or the unborn child.

Dichiarazioni precauzionali: P210u-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
5079255
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2934.99
TSCA
No

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