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93102-05-7 - N-Methoxymethyl-N-(trimethylsilylmethyl)benzylamine, 94% - L19412 - Alfa Aesar

L19412 N-Methoxymethyl-N-(trimethylsilylmethyl)benzylamine, 94%

Codice CAS
93102-05-7
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1g 34,34
5g 109,06
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N-Methoxymethyl-N-(trimethylsilylmethyl)benzylamine, 94%

MDL
MFCD00674005
EINECS
000-000-0

Proprietà chimiche

Formula
C13H23NOSi
Peso formula
237.42
Punto di ebollizione
76°/0.3mm
Punto di infiammabilità
66°(150°F)
Densità
0.928
Indice di rifrazione
1.4920
Sensibilità
Moisture & Light Sensitive
Solubilità
Soluble in chloroform, ethyl acetate.

Applicazioni

N-Methoxymethyl-N-(trimethylsilylmethyl)benzylamine forms azomethine ylides which readily undergo [3+2] cycloaddition to α,ß-unsaturated esters affording N-benzyl substituted pyrrolidines in good yields. It reacts with asymmetric 1,3-dipolar cycloadditions in the practical, large-scale synthesis of chiral pyrrolidines. It is used in the the synthesis of 3-carboxy-1-azabicyclo[2.2.1]heptane derivatives, an important class of physiologically active compounds.

Note

Moisture & Light Sensitive. Store away from oxidizing agents.

Letteratura

A. Stephen K. Hashmi; Dominic Riedel; Matthias Rudolph; Frank Rominger; Thomas Oeser. Regioselective Formation of Saturated Abnormal NHC-Gold(I) Complexes by [3+2] Cycloaddition of Azomethine Ylides and Isonitrile Gold(I) Complexes. Org. Biomol. Chem.2012, 18, 3827-3830.

Ultrasound treatment with LiF in acetonitrile generates an azomethine ylide which undergoes 1,3-dipolar cycloaddition to olefins to give pyrrolidine derivatives in good yield: J. Org. Chem., 52, 235 (1987). Also found use in the the synthesis of 3-carboxy-1-azabicyclo[2.2.1]heptane derivatives, an important class of physiologically active compounds: J. Org. Chem., 66, 2526 (2001).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Dichiarazioni precauzionali: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
4311216
Codice tariffe armonizzato
2931.90
TSCA
No

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