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269410-08-4 - 1H-Pyrazole-4-boronic acid pinacol ester, 98% - L19654 - Alfa Aesar

L19654 1H-Pyrazole-4-boronic acid pinacol ester, 98%

Codice CAS
269410-08-4
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1g 70,40
5g 235,40
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1H-Pyrazole-4-boronic acid pinacol ester, 98%

MDL
MFCD03453063

Proprietà chimiche

Formula
C9H15BN2O2
Peso formula
194.04
Punto di fusione
145-149°
Solubilità
Insoluble in water.

Applicazioni

1H-Pyrazole-4-boronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. It is also used as reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors as well as other biologically active compounds.

Note

Keep the container tightly sealed. Store in a cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Letteratura

Peter R. Mullens. An improved synthesis of 1-methyl-1H-pyrazole-4-boronic acid pinacol ester and its corresponding lithium hydroxy ate complex: application in Suzuki couplings. Tetrahedron Letters. 2009, 50 (49), 6783-6786.

Jongwon Lim.; Brandon Taoka.; Ryan D Otte.; Kerrie Spencer.; Christopher J Dinsmore.; Michael D Altman.; Grace Chan.; Craig Rosenstein.; Sujata Sharma.; Hua-Poo Su.; Alexander A Szewczak.; Lin Xu.; Hong Yin, Joan Zugay-Murphy.; C Gary Marshall.; Jonathan R Young. Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders. Journal of medicinal and pharmaceutical chemistry. 2011, 54 (20), 7334-7349.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2934.99
TSCA
No

Raccomandato

  • H53139

    1-Methyl-1H-pyrazole-4-boronic acid pinacol ester, 97%
  • H56369

    4-Iodo-1H-pyrazole, 99%

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