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6959-47-3 - 2-(Chloromethyl)pyridine hydrochloride, 98% - 2-Picolyl chloride hydrochloride - A10226 - Alfa Aesar

A10226 2-(Chloromethyl)pyridine hydrochloride, 98%

CAS 번호
6959-47-3
동의어
2-Picolyl chloride hydrochloride

사이즈 가격 ($) 수량 재고 여부
5g 30.70
25g 93.20
100g 253.00
장바구니에 추가 대량 견적에 추가 항목 보기

2-(Chloromethyl)pyridine hydrochloride, 98%

MDL
MFCD00012811
EINECS
230-149-9

화학적 특성

화학식
C6H6ClN•HCl
화학 식량
164.04
융점
120-124°
감도
Hygroscopic
용해도
Soluble in water, acetone (10-50mg/ml), 95%ethanol (100mg/ml).

용도

2-(Chloromethyl)pyridine hydrochloride was used as reagent in base catalyzed alkylation of p-tert-butylcalix[6]arene and p-tert-butylcalix[5]arene in DMF. It was used in the synthesis of Gd3+ diethylenetriaminepentaacetic acid bisamide complex, a Zn2+-sensitive magnetic resonance imaging contrast agent.

참고

Hygroscopic store in inert gas Store away from strong oxidizing agents. keep container tightly closed. Store in cool, dry conditions in well sealed containers.

참조 문헌

Neri P and Pappalardo S. Functionalization of p-tert-butylcalix [6] arene by alkylation with 2-(chloromethyl) pyridine hydrochloride. J. Org. Chem. 1993, 58,(5), 1048-53.

Pappalardo S and Ferguson G. Functionalization of p-tert-Butylcalix [5] arene by Alkylation with 2-(Chloromethyl) pyridine Hydrochloride. J. Org. Chem. 1996, 61,(7),2407-12.

Hanaoka K, et al. Selective sensing of zinc ions with a novel magnetic resonance imaging contrast agent. J. Chem. Soc. Perkin Trans. 2001, 9,1840-43.

The free base, generated from the hydrochloride with aqueous OH-, can be metallated (LDA, -78o) at the methylene group. Subsequent reaction with a ketone provides a route to otherwise inaccessible pyridyloxiranes: Tetrahedron Lett., 35, 3175 (1994). Similarly, reaction of the lithio derivative with an imine gives a pyridylaziridine, generally in good yield: J. Org. Chem., 60, 2279 (1995).

The free base has also been used for the protection of OH groups as 2-picolyl derivatives, relatively stable to acid (HF, TFA) but selectively cleaved by electrolytic reduction: Acta Chem. Scand. B, B37, 475 (1983); J. Chem. Res. (Synop.), 22 (1977).

For a study of the base-catalyzed alkylation of p-t-butylcalix[5]arene, see: J. Org. Chem., 61, 2407 (1996).

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H302-H314-H318

Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.

주의 설명서: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
3689155
위험 등급
8
포장 그룹
III
통합 관세 코드
2933.39
TSCA(독성물질규제법)"
No
RTECS(화학물질 독성 등록)
US6825000

권장

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    2-(Chloromethyl)quinoline hydrochloride, 97%
  • B23208

    2-(Aminomethyl)pyridine, 98+%

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