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108-18-9 - Diisopropylamine, 99+% - A10280 - Alfa Aesar

A10280 Diisopropylamine, 99+%

CAS 번호
108-18-9
동의어

사이즈 가격 ($) 수량 재고 여부
500ml 26.40
2500ml 81.50
장바구니에 추가 대량 견적에 추가 항목 보기

Diisopropylamine, 99+%

MDL
MFCD00008862
EINECS
203-558-5

화학적 특성

화학식
[(CH3)2CH]2NH
화학 식량
101.19
융점
-61°
비등점
83-84°
인화점
-7°(19°F)
밀도
0.718
굴절률
1.3920
용해도
Miscible with water.

용도

Diisopropylamine is used as a precursor to prepare lithium diisopropylamide and sulfenamides, which are used in rubber vulcanization. It is also involved in the synthesis of N,N-Diisopropylethylamine (Hünig's base) obtained by alkylation with diethyl sulfate. Diisopropylammonium bromide is a bromide salt of DIPA used as an inert alternative to barium titanate. It is widely used as solvent as well as an intermediate in the the synthesis of pharmaceuticals, dyes, mineral flotation agents and emulsifiers.

참고

Air sensitive. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and plastics.

참조 문헌

Precursor of the sterically-hindered strong base lithium diisopropylamide (LDA), which has a greater "kinetic-basicity" than some thermodynamically stronger bases, e.g. alkyllithiums, and therefore finds wide application in lithiation reactions. LDA is a particularly useful base for the preparation of carboxylic acid dianions and ester enolates. For a review, see: Synthesis, 521 (1982).

LDA is generally prepared in situ by reaction of diisopropylamine with an alkyllithium; numerous examples in Org. Synth. Coll., 6, 7, 8, 9, and subsequent annual volumes. For discussion of methods for preparation, including Li metal in the presence of an aromatic hydrocarbon as electron-acceptor, see: Synthesis, 463 (1979); see also (Li in ether): Liebigs Ann. Chem., 1471 (1980).

LDA cleaves 1,3-dithiolanes (ethylene dithioacetals) to the carbonyl compounds: Synthesis, 1087 (1982):

1,3-Dithianes are not cleaved under these conditions.

Lee, A.; Lundberg, P.; Klinger, D.; Lee, B. F.; Hawker, C. J.; Lynd, N. A. Physiologically relevant, pH-responsive PEG-based block and statistical copolymers with N,N-diisopropylamine units. Polym. Chem. 2013, 4 (24), 5735-5742.

Mei, L.; Peng, H. Y.; Song, S. Y.; Sun, Y. H.; Liu, Q. T.; Zhang, K.; Shi, Y. G. Study on the Nano Material Produced by Diisopropylamine or N Butyl Alcohol as Exchange Solvent. Adv. Mater. Res. 2012, 610-613, 530-533.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H225-H302-H331-H314-H318

Highly flammable liquid and vapour. Harmful if swallowed. Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.

주의 설명서: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,3196
바일슈타인
605284
위험 등급
3
포장 그룹
II
통합 관세 코드
2921.19
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
IM4025000

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