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107-19-7 - Propargyl alcohol, 99% - 2-Propyn-1-ol - A10295 - Alfa Aesar

A10295 Propargyl alcohol, 99%

CAS 번호
107-19-7
동의어
2-Propyn-1-ol

사이즈 가격 ($) 수량 재고 여부
100ml 13.30
500ml 33.10
2500ml 119.00
장바구니에 추가 대량 견적에 추가 항목 보기

Propargyl alcohol, 99%

MDL
MFCD00002912
EINECS
203-471-2

화학적 특성

화학식
C3H4O
화학 식량
56.06
융점
-53°
비등점
114-115°
인화점
33°(91°F)
밀도
0.949
굴절률
1.4320
용해도
Fully miscible in water.

용도

Propargyl alcohol is a solvent stabilizer that is useful as an intermediate in organic synthesis, an electroplating brightener additive. It is useful 3-carbon fragment in acetylene coupling reactions, It undergoes Pd-catalyzed O-coupling with alcohols to give the corresponding 1-methoxyallyl ethers.

참고

Store at 4°C. Incompatible with oxidizing agent, strong acids, strong bases, amines, phosphorous pentoxide, isocyanate vapor & heat.

참조 문헌

Yuji Kozawa; Miwako Mori. Synthesis of different ring-size heterocycles from the same propargyl alcohol derivative by ligand effect on Pd(0). Tetrahedron Letters. 2002, 43 1499-1502.

Useful 3-carbon fragment in acetylene coupling reactions. The hydroxyl group can be protected as its THP ether; see, e.g.: Org. Synth., 76, 178 (1998), or 1-ethoxyethyl ether (see Ethyl­ vinyl­ ether, A15691): Org. Synth., 76, 199 (1998). C-Alkylation can also be accomplished without O-protection by using 2 equivalents of base (LiNH2); see, e.g., J. Chem. Soc., Perkin 1, 85 (1988); Org. Synth. Coll., 8, 415 (1993).

O-methylation, followed by treatment with t-BuOK affords methoxyallene, a valuable reactive intermediate. It undergoes Pd-catalyzed O-coupling with alcohols to give the corresponding 1-methoxyallyl ethers: Synlett, 192 (1998). Lithiation leads to 1-lithio-1-methoxyallene: J. Org. Chem., 50, 5308 (1985); 58, 6377 (1993). For a brief feature on methoxyallene with further examples, see: Synlett, 1697 (2000).

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H226-H301-H311-H331-H314

Flammable liquid and vapour. Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes severe skin burns and eye damage.

주의 설명서: P210-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,7809
바일슈타인
506003
위험 등급
6.1
포장 그룹
II
통합 관세 코드
2905.29
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
UK5075000

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