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128-09-6 - N-Chlorosuccinimide, 98% - NCS - A10310 - Alfa Aesar

A10310 N-Chlorosuccinimide, 98%

CAS 번호
128-09-6
동의어
NCS

사이즈 가격 ($) 수량 재고 여부
50g 15.40
250g 36.40
1000g 134.00
장바구니에 추가 대량 견적에 추가 항목 보기

N-Chlorosuccinimide, 98%

MDL
MFCD00005511
EINECS
204-878-8

화학적 특성

화학식
C4H4ClNO2
화학 식량
133.53
융점
146-150°
밀도
1.65
감도
Moisture Sensitive
용해도
Soluble in water, alcohol, benzene, acetone and acetic acid. Slightly soluble in ether, chloroform, carbon tetrachloride and petroleum ether.

용도

Regioselective chlorination and oxidizing reagentN-Chlorosuccinimide is used as a chlorinating agent, mild oxidant and swimming pool disinfectant. It is used in the microdetermination of hydrazine salts by titrimetry as well as in the detection of arsenic in the +3 oxidative state. It is also employed in the production of rubber additives. Further, it is used as pharmaceutical intermediate and antibiotic drugs intermediate.

참고

Light sensitive and moisture sensitive. Incompatible with strong oxidizing agents, strong acids, strong bases, amines, ammonia, iron and iron salts.

참조 문헌

Source of positive chlorine in chlorination and oxidation reactions.

Methyl ketones may be monochlorinated via their Li enolates: J. Org. Chem., 49, 1286 (1984). For the ɑ-chlorination of acid chlorides formed in situ, see: Tetrahedron Lett., 3235 (1974). For chlorination of deactivated anilines, see: Synthesis, 669 (1985).

In the presence of triphenylphosphine or triphenyl phosphite, converts alcohols to alkyl chlorides stereospecifically with inversion: Tetrahedron Lett., 3937 (1973). For a review, see: Org. React., 29, 1 (1983). Amides have been prepared by treatment of a carboxylic acid with NCS/PPh3 followed by an amine: Synth. Commun., 25, 959 (1995).

With dimethyl sulfide, forms the Corey-Kim reagent, a mild, selective oxidant for alcohols. For a review, see: Synthesis, 857 (1990); for tabulated examples, see: Org. Synth. Coll., 6, 220 (1988).

Primary alcohols are oxidized cleanly to aldehydes using NCS and a catalytic amount of TEMPO, A12733 under phase-transfer conditions: J. Org. Chem., 61, 7452 (1996).

NCS in ether is a convenient alternative to hypochlorite for the conversion of amines to N-chloroamines, for use, e.g. in the Hofmann-Loeffler reaction, see: Chem. Ber., 88, 883 (1955).

Yu, J.; Shin, G. A.; Oh, B. S.; Kye, J. I.; Yoon, J. N-chlorosuccinimide as a novel agent for biofouling control in the polyamide reverse osmosis membrane process. Desalination 2015, 357, 1-7.

Ravi, C.; Chandra Mohan, D.; Adimurthy, S. N-Chlorosuccinimide-Promoted Regioselective Sulfenylation of Imidazoheterocycles at Room Temperature. Org. Lett. 2014, 16 (11), 2978-2981.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H302-H314-H318

Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.

주의 설명서: P280-P305+P351+P338-P309-P310a

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER/doctor

기타 참조

Merck
14,2164
바일슈타인
113915
위험 등급
8
포장 그룹
II
통합 관세 코드
2925.19
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
UY1013500

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