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6066-82-6 - N-Hydroxysuccinimide, 98+% - HOSu - 1-Hydroxy-2,5-pyrrolidinedione - A10312 - Alfa Aesar

A10312 N-Hydroxysuccinimide, 98+%

CAS 번호
6066-82-6
동의어
HOSu
1-Hydroxy-2,5-pyrrolidinedione

사이즈 가격 ($) 수량 재고 여부
25g 33.80
100g 90.70
500g 362.00
장바구니에 추가 대량 견적에 추가 항목 보기

N-Hydroxysuccinimide, 98+%

MDL
MFCD00005516
EINECS
228-001-3

화학적 특성

화학식
C4H5NO3
화학 식량
115.09
융점
94-99°
감도
Hygroscopic
용해도
Soluble in water, dimethyl formamide, alcohols and ethyl acetate. Insoluble in cold ether.

용도

N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings.

참고

Hygroscopic. Moisture sensitive. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides and strong bases. Store in a cool place.

참조 문헌

Reagent for the preparation of active N-hydroxysuccinimide esters for peptide coupling with minimum racemization: J. Am. Chem. Soc., 86, 1839 (1964), or as an additive in the DCC method (see N,N'-Dicyclohexyl­carbodiimide, A10973 ) to suppress racemization: J. Am. Chem. Soc., 89, 7151 (1967). For peptide reagents, see Appendix 6.

For a study of the aminolysis of N-hydroxysuccinimide esters, see: J. Org. Chem., 53, 3583 (1988).

Park, C.; Vo, C. L. N.; Kang, T.; Oh, E.; Lee, B. J. New method and characterization of self-assembled gelatin-oleic nanoparticles using a desolvation method via carbodiimide/N-hydroxysuccinimide (EDC/NHS) reaction. Eur. J. Pharm. Biopharm. 2015, 89, 365-373.

Peng, Z.; McGee, W. M.; Bu, J.; Barefoot, N. Z.; McLuckey, S. A. Gas phase reactivity of carboxylates with N-hydroxysuccinimide esters. J. Am. Soc. Mass. Spectrom. 2015, 26 (1), 174-180.

기타 참조

바일슈타인
113913
통합 관세 코드
2925.19
TSCA(독성물질규제법)"
Yes

권장

  • A10807

    1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 98+%
  • A10973

    N,N'-Dicyclohexylcarbodiimide, 99%
  • A12646

    Triethylamine, 99%
  • A13016

    4-(Dimethylamino)pyridine, 99%
  • 43998

    Dimethyl sulfoxide, anhydrous, 99.8+%, packaged under Argon in resealable ChemSeal™ bottles

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