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6148-64-7 - Ethyl potassium malonate, 98% - Malonic acid monoethyl ester potassium salt - Monoethyl malonate potassium salt - A10720 - Alfa Aesar

A10720 Ethyl potassium malonate, 98%

CAS 번호
6148-64-7
동의어
Malonic acid monoethyl ester potassium salt
Monoethyl malonate potassium salt

사이즈 가격 ($) 수량 재고 여부
25g 50.60
100g 165.00
500g 716.00
장바구니에 추가 대량 견적에 추가 항목 보기

Ethyl potassium malonate, 98%

MDL
MFCD00035603
EINECS
228-156-7

화학적 특성

화학식
C5H7KO4
화학 식량
170.21
융점
ca 200° dec.
감도
Hygroscopic
용해도
Soluble in water.

용도

Ethyl potassium malonate is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation. Further, it reacts with aryl nitriles to prepare beta-amino acrylates in the presence of zinc chloride and a catalytic amount of Hünig's base. In addition to this, it serves as an intermediate for the preparation of ethyl tert-butyl malonate.

참고

Hygroscopic. Incompatible with strong oxidizing agents.

참조 문헌

An improved method for acylation with acid chlorides utilizes the Rathke MgCl2-triethylamine reagent in acetonitrile or ethyl acetate to give ß-keto esters in very high yields: Synthesis, 290 (1993):

Compare Diethyl­ malonate, A15468 and Dimethyl­ malonate, A11007, for other applications of this technique. See also Ethyl­ hydrogen malonate, A12627.

Alternatively, ß-keto esters can be obtained in high yield by reaction with TMS chloride to generate ethyl trimethylsilyl malonate, followed by in situ reaction with acyl imidazoles or acyl chlorides in the presence of DBU: Tetrahedron Lett., 35, 9323 (1994).

Tancock, J.; Wirth, T. Selenium-Mediated Synthesis of Tetrasubstituted Naphthalenes through Rearrangement. Molecules 2015, 20 (6), 10866-10872.

Stasyuk, A. J.; Smoleń, S.; Glodkowska-Mrowka, E.; Brutkowski, W.; Cyrański, M. K.; Tkachenko, N.; Gryko, D. T. Synthesis of Fluorescent Naphthoquinolizines via Intramolecular Houben-Hoesch Reaction. Chem. Asian J. 2015, 10 (3), 553-558.

기타 참조

바일슈타인
3721682
통합 관세 코드
2917.19
TSCA(독성물질규제법)"
No

권장

최근에 본 것

화학물질

화학물질

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