A10837 1-Methylpiperazine, 98+%

CAS 번호

109-01-3

동의어

Stock No.	사이즈	가격 ($)
A10837-AE	100ml	24.20
A10837-AP	500ml	102.00
A10837-0F	2500ml	418.00

장바구니에 추가 대량 견적에 추가 항목 보기

1-Methylpiperazine, 98+%

MDL

MFCD00005966

EINECS

203-639-5

화학적 특성

화학식

C₅H₁₂N₂

화학 식량

100.17

융점

-6°

비등점

137-139°

인화점

34°(93°F)

밀도

0.903

굴절률

1.4655

Storage & Sensitivity

Air Sensitive. Store under Argon. Ambient temperatures.

용해도

Miscible with water and methanol.

용도

1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

참고

Hygroscopic. Moisture sensitive. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents and carbon dioxide.

참조 문헌

For preparation of a reagent for the high-yield reduction of esters to aldehydes, see Sodium bis(2-methoxyethoxy)aluminum hydride, A13292. Similarly, addition of the hydrochloride to Lithium aluminum hydride, A18116, gives a complex which can reduce carboxylic acids to aldehydes: J. Org. Chem., 49, 2279 (1984).

The N-lithio-derivative effects the O-alkyl cleavage of aromatic ortho-alkoxyaldehydes or ketones, without the need for carbonyl protection: Synth. Commun., 18, 191 (1988).

Li, H.; Le Moullec, Y.; Lu, J.; Chen, J.; Marcos, J. C. V.; Chen, G.; Chopin, F. CO₂ solubility measurement and thermodynamic modeling for 1-methylpiperazine/water/CO₂. Fluid Phase Equilib. 2015, 394, 118-128.

Kovalev, V. V.; Gorbunova, Y. E.; Kokunov, Y. V. Silver nitrate coordination polymer with 1-methylpiperazine: Synthesis and crystal structure. Russ. J. Inorg. Chem. 2015, 60 (7), 886-888.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H226-H302-H312-H331-H314-H318

Flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.

주의 설명서: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.