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127-19-5 - N,N-Dimethylacetamide, 99% - DMA - A10924 - Alfa Aesar

A10924 N,N-Dimethylacetamide, 99%

CAS 번호
127-19-5
동의어
DMA

사이즈 가격 ($) 수량 재고 여부
250ml 21.00
500ml 26.80
2500ml 86.20
장바구니에 추가 대량 견적에 추가 항목 보기

N,N-Dimethylacetamide, 99%

MDL
MFCD00008686
EINECS
204-826-4

화학적 특성

화학식
C4H9NO
화학 식량
87.12
융점
-20°
비등점
165-166°
인화점
70°(158°F)
밀도
0.940
굴절률
1.4385
용해도
Miscible with water, benzene, alcohol, acetone, ether, esters and ketones.

용도

N,N-Dimethylacetamide is used as a polar solvent in organic synthesis as well as in reactions involving strong bases such as sodium hydroxide. It is also used as a solvent for fibers like polyacrylonitrile, spandex, as an excipient in drugs viz. vumon, busulfex and in the adhesive industry. It finds application as a reaction medium in the production of pharmaceuticals, agrochemicals, dyes and plasticizers. It is widely used in polymer industry due to its high solving power for high molecular-weight polymers and synthetic resins. It plays an important role as a catalyst in various reactions viz. cyclization, halogenation, cynidation, alkylation and dehydrogenation and increases the yield of main products. It is also used as an extracting agent for oil and gases, in paint removers, in the production of photo-resist stripping compounds and as booster solvent in coatings.

참고

Hygroscopic. Incompatible with strong oxidizing agents.

참조 문헌

Dipolar aprotic solvent, cf N,N-Dimethyl­formamide, A13547, Dimethyl­ sulfoxide, A13280, 1-Methyl-2-pyrrolidinone, A12260.

See also Sodium hydride, 13431, for warning.

Useful solvent in halex fluorinations of chloroarenes; compare Sulfolane, A13466.

Undergoes Vilsmeier-type reactions (compare DMF), with reactive substrates, introducing an acetyl group: Chem. Ber., 97, 616 (1964).

Reacts with alkyl and aryl Grignard reagents to give methyl ketones in good yields: Synthesis, 228 (1984).

In the presence of triflic anhydride and 2,4,6-collidine, forms a highly-reactive keteniminium triflate, which undergoes a [2+2] cycloaddition reaction with terminal alkenes to give, after hydrolysis a 3-alkylcyclobutanone: J. Am. Chem. Soc., 107, 2192 (1985); Org. Synth. Coll., 8, 306 (1993):

Messaadi, A.; Salhi, H.; Das, D.; Alzamil, N. O.; Alkhaldi, M. A.; Ouerfelli, N.; Hamzaoui, A. H. A novel approach to discuss the viscosity Arrhenius behaviour and to derive the partial molar properties in binary mixtures of N, N-dimethylacetamide with 2-methoxyethanol in the temperature interval (from 298.15 to 318.15) K. Phys. Chem. Liq. 2015, 53 (4), 506-517.

Shokouhi, M.; Farahani, H.; Jenab, M. H.; Jalili, A. H. Solubility of Hydrogen Sulfide in N-Methylacetamide and N, N-Dimethylacetamide: Experimental Measurement and Modeling. J. Chem. Eng. Data 2015, 60 (3), 499-508.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H227-H312-H332-H360

Combustible liquid. Harmful in contact with skin. Harmful if inhaled. May damage fertility or the unborn child.

주의 설명서: P210u-P201-P261-P280-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

Merck
14,3227
바일슈타인
1737614
통합 관세 코드
2924.19
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
AB7700000

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