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10236-14-3 - Triethyl 4-phosphonocrotonate, cis + trans, 94% - 4-Phosphonocrotonic acid triethyl ester - Triethyl trans-4-phosphono-2-butenoate - A10995 - Alfa Aesar

A10995 Triethyl 4-phosphonocrotonate, cis + trans, 94%

CAS 번호
10236-14-3
동의어
4-Phosphonocrotonic acid triethyl ester
Triethyl trans-4-phosphono-2-butenoate

사이즈 가격 ($) 수량 재고 여부
10g 81.90
25g 157.00
250g 1308.00
장바구니에 추가 대량 견적에 추가 항목 보기

Triethyl 4-phosphonocrotonate, cis + trans, 94%

MDL
MFCD00009192

화학적 특성

화학식
C10H19O5P
화학 식량
250.23
비등점
133-135°/0.4mm
인화점
>110°(230°F)
밀도
1.130
굴절률
1.4550

용도

Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

참고

Stable under recommended storage conditions. Incompatible with oxidizing agents.

참조 문헌

Xiao-Ping Song; Camille Bouillon; Eveline Lescrinier; Piet Herdewijn. Iminodipropionic acid as the leaving group for DNA polymerization by HIV-1 reverse transcriptase. ChemBioChem. 2011, 12,(12), 1868-1880.

 

George Kokotos; Yuan-Hao Hsu; John E.Burke; Constantinos Baskakis; Christoforos G.Kokotos; Victoria Magrioti; Edward A.Dennis. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. Journal of medicinal and pharmaceutical chemistry. 2010, 53,(9), 3602-3610.

Wadsworth-Emmons reaction with carbonyl compounds leads to conjugated dienoic esters. Use of LiHMDS or LDA as base results in a high proportion of the (E,E)-isomer: J. Am. Chem. Soc., 100, 3599 (1978).

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

통합 관세 코드
2931.39
TSCA(독성물질규제법)"
No

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